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Immunologic Classification of Acute Lymphoblastic Leukemia in Korean : 급성 림프구성 백혈병의 면역학적 분류
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- Authors
- Issue Date
- 1987-06
- Citation
- Seoul J Med, Vol.28 No.2, pp. 109-114
- Abstract
- Recent advance in immunology has led to important insight into lymphocyte
differentiation and the cellular origin of acute lymphoblastic leukemia(ALl). Leukemic cells
from 68 children and 60 adults with ALL were analyzed utilizing highly specific monoclonal
antibodies, terminal deoxynucleotidyl transferase and more traditional lymphocyte markers
such as sheep erythrocyte receptor and surface membrane immunoglobulin. Monoclonal antibodies
used were J5 detecting common ALL antigen (CALLA), OKT10, OKM1 and OKla 1
detecting HLA-DR. Four major subgroups of ALL were identified: in childhood ALL, common
ALL (58.8%), null ALL (20.6%), T-ALL (19.1%) and B-ALL (1.5%) and in adult ALL, common
ALL (60.0%), null ALL (25.0%), T-ALL (13.3%) and B-ALL 0.7%). The frequencies of expression
of the markers within each of the four major subgroups were also evaluated. In
T-ALL, 18% of childhood and 25% of adult cases expressed CALLA.
- ISSN
- 0582-6802
- Language
- English
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