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Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches

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dc.contributor.authorCho, Sun-A-
dc.contributor.authorPark, Jong-Hwan-
dc.contributor.authorSeok, Seung-Hyeok-
dc.contributor.authorJuhn, Jae-Hyeon-
dc.contributor.authorKim, Seong-Jin-
dc.contributor.authorJi, Hyi-Jeong-
dc.contributor.authorChoo, Youn-Sung-
dc.contributor.authorPark, Jae Hak-
dc.date.accessioned2009-08-07T02:47:52Z-
dc.date.available2009-08-07T02:47:52Z-
dc.date.issued2006-01-18-
dc.identifier.citationExperimental and Toxicologic Pathology 2006;57:321–328en
dc.identifier.issn0940-2993-
dc.identifier.issnhttp://dx.doi.org/10.1016/j.etp.2005.09.006-
dc.identifier.urihttps://hdl.handle.net/10371/6472-
dc.description.abstractThe present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 μg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.en
dc.description.sponsorshipThis work was supported by LG Life Sciences Ltd. and Brain Korea 21 project.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectMucositisen
dc.subjectGM-CSFen
dc.subject5-FUen
dc.subjectHamster buccal pouchen
dc.subjectImmunohistochemistryen
dc.titleEffect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouchesen
dc.typeArticleen
dc.contributor.AlternativeAuthor조선아-
dc.contributor.AlternativeAuthor박종환-
dc.contributor.AlternativeAuthor석승혁-
dc.contributor.AlternativeAuthor전재현-
dc.contributor.AlternativeAuthor김성진-
dc.contributor.AlternativeAuthor지희정-
dc.contributor.AlternativeAuthor추연선-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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