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Expression of MAP Kinases and Connexins in the Differentiation of Rat Mammary Epithelial Cells

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dc.contributor.authorSeo, Min-Soo-
dc.contributor.authorPark, Joon-Suk-
dc.contributor.authorYang, Se-Ran-
dc.contributor.authorPark, Ki-Su-
dc.contributor.authorHong, In-Sun-
dc.contributor.authorJo, Eun-Hye-
dc.contributor.authorKang, Kyung-Sun-
dc.contributor.authorLee, Yong Soon-
dc.date.accessioned2009-08-07T03:29:18Z-
dc.date.available2009-08-07T03:29:18Z-
dc.date.issued2006-
dc.identifier.citationJ. Vet. Med. Sci.68: 567-571en
dc.identifier.issn0916-7250 (print)-
dc.identifier.issn1347-7439 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/6491-
dc.description.abstractGap junctional intercellular communication (GJIC) is involved in the regulation of many cellular processes. MAP kinases are known to affect GJIC and phosphorylation of connexin (Cx). MAP kinases can also be a regulator of cell proliferation and growth. This study was undertaken to show the relevance between expression patterns of Cxs and MAP kinases in rat mammary epithelial cells (RMECs). In order to characterize the RMECs, they were stained with Peanut lectin, which indicates most alveolar epithelial cells, and Thy-1.1 was used as a marker of luminal epithelial cells or myoepithelial cells, respectively. We studied the expression patterns of major gap junction proteins, Cx 26, 32, and 43 in RMECs. Western blot analysis demonstrated that Cx26 gradually decreased from day 2, while Cx32 was expressed constantly from day 1 to 14. Cx43 dramatically increased on day 5 and decreased thereafter. The expression patterns and phosphorylation of ERK1/2 and JNK were similar to Cx43, but expression of p38 was like that of Cx32. These results showed that the MAP kinases that comprise ERK1/2, p38, and JNK were involved in regulation of Cxs. Our data suggests that GJIC plays an important role during rat mammary differentiation and that MAP kinases may be closely related functionally to regulate the gap junction.en
dc.description.sponsorshipThis work was supported by a Korea Research Foundation grant (KRF-005-E00076), Brain Korea 21 Project grant, and the Korea Health 21 R&D Project grant, Ministry of Health & Welfare, Republic of Korea (02-PJ10-PG4-PT02-0015).en
dc.language.isoen-
dc.publisherJapanese Society of Veterinary Scienceen
dc.subjectconnexinen
dc.subjectgap junctionen
dc.subjectMAP kinaseen
dc.subjectrat mammary epithelial cellen
dc.titleExpression of MAP Kinases and Connexins in the Differentiation of Rat Mammary Epithelial Cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor서민수-
dc.contributor.AlternativeAuthor박준석-
dc.contributor.AlternativeAuthor양세란-
dc.contributor.AlternativeAuthor박기수-
dc.contributor.AlternativeAuthor홍인선-
dc.contributor.AlternativeAuthor조은혜-
dc.contributor.AlternativeAuthor강경선-
dc.contributor.AlternativeAuthor이영순-
dc.identifier.doi10.1292/jvms.68.567-
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