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Immunostimulatory Effects of the Anionic Alkali Mineral Complex BARODON on Equine Lymphocytes

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dc.contributor.authorKoo, HyeCheong-
dc.contributor.authorRyu, Seung-Ho-
dc.contributor.authorAhn, Hyung Jin-
dc.contributor.authorJung, Woo Kyung-
dc.contributor.authorPark, Young Kyung-
dc.contributor.authorKwon, Nam Hoon-
dc.contributor.authorKim, So Hyun-
dc.contributor.authorKim, Jun Man-
dc.contributor.authorYoo, Byung Woo-
dc.contributor.authorChoi, Soo Il-
dc.contributor.authorDavis, William C.-
dc.contributor.authorPark, Yong Ho-
dc.date.accessioned2009-08-07T06:49:35Z-
dc.date.available2009-08-07T06:49:35Z-
dc.date.issued2006-
dc.identifier.citationClin. Vaccine Immunol. 13:1255-1266en
dc.identifier.issn1071-412X-
dc.identifier.urihttps://hdl.handle.net/10371/6519-
dc.description.abstractPrevious studies have shown that the anionic alkali mineral complex BARODON has an immunoenhancing effect on pigs as an adjuvant and as a nonspecific immunostimulant. Likewise, the equine immune system has been defined with various monoclonal antibodies specific to equine leukocyte differentiation antigens to determine the possibility of enhancing equine resistance to respiratory diseases and promoting other immunostimulatory effects with the application of BARODON. Compared with the control group, after 3 weeks of treatment, BARODON-treated groups showed higher proportions of cells (P < 0.05) expressing major histocompatibility complex class II and CD2, CD4+, CD4+ CD25+, CD8+, and CD8+ CD25+ T lymphocytes, dendritic cells, and surface immunoglobulin M+ B lymphocytes in peripheral blood, as well as enhanced cell proliferative responses with phytohemagglutinin and increased phagocytic activity against Streptococcus equi and Staphylococcus aureus strains with high antibiotic resistance, the bacteria frequently identified as etiologic agents of equine respiratory diseases at the Seoul Race Park in Seoul, Korea. This study shows that BARODON may act as an immunostimulator and can be an effective alternative to antimicrobial feed additives for nonspecific improvements in equine immune responses, particularly against respiratory diseases.en
dc.description.sponsorshipWe thank Sook Shin and Yang Hee Kim for outstanding technical
assistance and the many veterinarians of the Korea Racing Association
who helped to collect equine blood and check clinical observations
during this study.
This study was supported in part by funding from Agribrands Purina
Korea Inc. and by the Brain Korea 21 program for Veterinary Science
and the Research Institute for Veterinary Science, College of Veterinary
Medicine, Seoul National University. Further support was also
provided by the Korea Research Foundation (grant KRF-2006-005-
J0293).
en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.titleImmunostimulatory Effects of the Anionic Alkali Mineral Complex BARODON on Equine Lymphocytesen
dc.typeArticleen
dc.contributor.AlternativeAuthor구혜청-
dc.contributor.AlternativeAuthor류승호-
dc.contributor.AlternativeAuthor안형진-
dc.contributor.AlternativeAuthor정우경-
dc.contributor.AlternativeAuthor박영경-
dc.contributor.AlternativeAuthor권남훈-
dc.contributor.AlternativeAuthor김소현-
dc.contributor.AlternativeAuthor김준만-
dc.contributor.AlternativeAuthor유병우-
dc.contributor.AlternativeAuthor최수일-
dc.contributor.AlternativeAuthor박용호-
dc.identifier.doi10.1128/CVI.00150-06-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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