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Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae
DC Field | Value | Language |
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dc.contributor.author | Kim, Min-Chul | - |
dc.contributor.author | Kwon, Yong-Kuk | - |
dc.contributor.author | Joh, Seong-Joon | - |
dc.contributor.author | Lindberg, A. Michael | - |
dc.contributor.author | Kwon, Jun-Hun | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.contributor.author | Kim, Sun-Joong | - |
dc.date.accessioned | 2009-08-07T07:04:53Z | - |
dc.date.available | 2009-08-07T07:04:53Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | J Gen Virol 87, 3307–3316 | en |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6528 | - |
dc.description.abstract | Duck hepatitis virus type 1 (DHV-1) was previously classified as an enterovirus, based primarily
on observed morphology and physicochemical properties of the virion. The complete nucleotide sequences of two strains (DRL-62 and R85952) of DHV-1 have been determined. Excluding the poly(A) tail, the genomes are 7691 and 7690 nt, respectively, and contain a single, large open reading frame encoding a polyprotein of 2249 aa. The genome of DHV-1 is organized as are those of members of the family Picornaviridae: 59 untranslated region (UTR)–VP0–VP3– VP1–2A1–2A2–2B–2C–3A–3B–3C–3D–39 UTR. Analysis of the genomic and predicted polyprotein sequences revealed several unusual features, including the absence of a predicted maturation cleavage of VP0, the presence of two unrelated 2A protein motifs and a 39 UTR extended markedly compared with that of any other picornavirus. The 2A1 protein motif is related to the 2A protein type of the genus Aphthovirus and the adjacent 2A2 protein is related to the 2A protein type present in the genus Parechovirus. Phylogenetic analysis using the 3D protein sequence shows that the two DHV-1 strains are related more closely to members of the genus Parechovirus than to other picornaviruses. However, the two DHV-1 strains form a monophyletic group, clearly distinct from members of the genus Parechovirus. | en |
dc.description.sponsorship | The authors would like to thank Hyuk-Man Kwon for propagation of DHV samples and Dr Bang-Hun Hyun for support of the genetic analysis. This work was supported financially by the National Veterinary Research and Quarantine Service (NVRQS), Ministry of Agricultural and Forestry (MAF), Republic of Korea. A. M. L. was supported by the Knowledge Foundation, Sweden, and the Research Programme in Medical Bioinformatics, Karolinska Institute, Stockholm, Sweden. | en |
dc.language.iso | en | en |
dc.publisher | Society for General Microbiology | en |
dc.title | Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김민철 | - |
dc.contributor.AlternativeAuthor | 권용국 | - |
dc.contributor.AlternativeAuthor | 조성준 | - |
dc.contributor.AlternativeAuthor | 권준헌 | - |
dc.contributor.AlternativeAuthor | 김재홍 | - |
dc.contributor.AlternativeAuthor | 김선중 | - |
dc.identifier.doi | 10.1099/vir.0.81804-0 | - |
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