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Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Ha, Y. | - |
dc.contributor.author | Chae, Chan Hee | - |
dc.date.accessioned | 2009-08-07T08:15:46Z | - |
dc.date.available | 2009-08-07T08:15:46Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Vet Pathol 43:718-725, 2006 | en |
dc.identifier.issn | 0300-9858 | - |
dc.identifier.uri | http://www.vetpathology.org/cgi/content/abstract/43/5/718 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6549 | - |
dc.description.abstract | This study investigated the potentiation of porcine circovirus 2 (PCV2)-induced
postweaning multisystemic wasting syndrome by porcine parvovirus (PPV) and found it was associated with excessive production of tumor necrosis factor-a (TNF-a). Colostrum-deprived conventional pigs were inoculated intranasally with PCV2 or PPV alone or in combination (PCV2 and PPV). In vitro assay of TNF-a, obtained from alveolar macrophages coinfected with PCV2 and PPV, showed a significant increase in TNF-a compared to single infection of macrophages with either PCV2 or PPV alone (P , 0.05). All pigs inoculated with PCV2 and PPV developed severe postweaning wasting syndrome, whereas clinical signs (e.g., weight loss) were present but perhaps less severe in either PCV2- or PPV-inoculated pigs. Compared to the pigs inoculated with PCV2 or PPV alone, pigs inoculated dually with PCV2 and PPV showed significantly (P , 0.05) increased levels of TNF-a. Levels of TNF-a in the sera were reversely correlated with the body weight in pigs experimentally infected with dual inoculation of PCV2 and PPV (rs 5 20.92, P , 0.001). These data suggest that a potentiation of PPV in PCV2-induced PMWS is associated with the excessive production of TNF-a. | en |
dc.description.sponsorship | The research reported here was supported by
Ministry of Agriculture, Forestry and Fisheries-Special Grants Research Program (MAFF-SGRP) and Brain Korea 21 Project, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | American College of Veterinary Pathologists | en |
dc.subject | Porcine circovirus | en |
dc.subject | porcine parvovirus | en |
dc.subject | postweaning multisystemic wasting syndrome | en |
dc.subject | swine | en |
dc.subject | tumor necrosis factor-a | en |
dc.title | Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 채찬희 | - |
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