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Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha

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dc.contributor.authorKim, J.-
dc.contributor.authorHa, Y.-
dc.contributor.authorChae, Chan Hee-
dc.date.accessioned2009-08-07T08:15:46Z-
dc.date.available2009-08-07T08:15:46Z-
dc.date.issued2006-
dc.identifier.citationVet Pathol 43:718-725, 2006en
dc.identifier.issn0300-9858-
dc.identifier.urihttp://www.vetpathology.org/cgi/content/abstract/43/5/718-
dc.identifier.urihttps://hdl.handle.net/10371/6549-
dc.description.abstractThis study investigated the potentiation of porcine circovirus 2 (PCV2)-induced
postweaning multisystemic wasting syndrome by porcine parvovirus (PPV) and found it was associated
with excessive production of tumor necrosis factor-a (TNF-a). Colostrum-deprived conventional pigs
were inoculated intranasally with PCV2 or PPV alone or in combination (PCV2 and PPV). In vitro assay
of TNF-a, obtained from alveolar macrophages coinfected with PCV2 and PPV, showed a significant
increase in TNF-a compared to single infection of macrophages with either PCV2 or PPV alone (P ,
0.05). All pigs inoculated with PCV2 and PPV developed severe postweaning wasting syndrome, whereas
clinical signs (e.g., weight loss) were present but perhaps less severe in either PCV2- or PPV-inoculated
pigs. Compared to the pigs inoculated with PCV2 or PPV alone, pigs inoculated dually with PCV2 and
PPV showed significantly (P , 0.05) increased levels of TNF-a. Levels of TNF-a in the sera were
reversely correlated with the body weight in pigs experimentally infected with dual inoculation of PCV2
and PPV (rs 5 20.92, P , 0.001). These data suggest that a potentiation of PPV in PCV2-induced
PMWS is associated with the excessive production of TNF-a.
en
dc.description.sponsorshipThe research reported here was supported by
Ministry of Agriculture, Forestry and Fisheries-Special
Grants Research Program (MAFF-SGRP) and Brain
Korea 21 Project, Republic of Korea.
en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Pathologistsen
dc.subjectPorcine circovirusen
dc.subjectporcine parvovirusen
dc.subjectpostweaning multisystemic wasting syndromeen
dc.subjectswineen
dc.subjecttumor necrosis factor-aen
dc.titlePotentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alphaen
dc.typeArticleen
dc.contributor.AlternativeAuthor채찬희-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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