Publications
Detailed Information
Effect of Ketamine on the Acetylcholine Concentration of Various Regions of Rat Brain : Ketamine이 백서뇌 부위별 Acetylcholine 함량에 미치는 영향
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 1987-12
- Citation
- Seoul J Med, Vol.28 No.4, pp. 347-351
- Keywords
- Acetylcholine ; Rat brain ; Behavior
- Abstract
- After Ketamine administration (30 mg/kg, intraperitoneally), acetylcholine (ACh)
concentrations did not change significantly at 10 min, but started to decrease in several brain
regions at 30 min, .ind decreased markedly in all regions at 60 min. ACh levels returned to
almost normal after 4 hrs. The decrease was most marked in pons-medulla, cerebral cortex,
hippocampus, and corpus striatum. In these regions, a dose (5 mg/kg, intraperitoneally) far
below the anesthetic doses decreased ACh levels as much as 30 mg/kg. The derease in ACh
levels induced by ketamine may be associated with hallucination, delirium, dream, amnesia,
and analgesia which occur in humans at subanesthetic doses of ketamine and during recovery
from ketamine anesthesia.
Key words: Ketamine. Acetylcholine
- ISSN
- 0582-6802
- Language
- English
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.