S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 12 No.3 (1971)
흰쥐 신장 MIcrosomal fraction ATPase 활성에 대한 연구
Studies on ATPase activity of rat kidney microsomal fraction.
- 박찬웅; 오진설; 문익주
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.12 No.3, pp. 166-172
- The effects of ethacrynic acid, furosemide and ouabain on ATPase activity of rat microsomal fraction
were studied in order to confirm the evidence of relation
between effect on ATPase activity and their
Ethacrynic acid and furosemide inhibit rat kidney
microsomal ATPase activity and degree of their inhibitory
action was dependent on K+ concentration in
Ouabain shows no inhibitory action on ATPase activity
but slight stimulation. Mgt t-A'I'Pase activity
was inhibited by ouabain.
It suggest that the inhibition of kidney microsomal
ATPase activity by ethacrynic acid and furosemide
will partly contribute to their diuretic action through
inhibition of tubular sodium reabsorption mechanism.