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흰쥐 신장 MIcrosomal fraction ATPase 활성에 대한 연구 : Studies on ATPase activity of rat kidney microsomal fraction.
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- Authors
- Issue Date
- 1971-09
- Publisher
- 서울대학교 의과대학
- Citation
- Seoul J Med, Vol.12 No.3, pp. 166-172
- Abstract
- The effects of ethacrynic acid, furosemide and ouabain on ATPase activity of rat microsomal fraction
were studied in order to confirm the evidence of relation
between effect on ATPase activity and their
diuretic action.
Ethacrynic acid and furosemide inhibit rat kidney
microsomal ATPase activity and degree of their inhibitory
action was dependent on K+ concentration in
the medium.
Ouabain shows no inhibitory action on ATPase activity
but slight stimulation. Mgt t-A'I'Pase activity
was inhibited by ouabain.
It suggest that the inhibition of kidney microsomal
ATPase activity by ethacrynic acid and furosemide
will partly contribute to their diuretic action through
inhibition of tubular sodium reabsorption mechanism.
- ISSN
- 0582-6802
- Language
- Korean
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