급성 일산화탄소중독에 있어 치료효과에 관한 실험적 연구

Abstract

This experiment is to ascertain the therapeutic effectiveness of the administration of 2-Pyrrolidone acetamide in the treatment of acute carbon monoxide poisoning using rats. The results are summarized as follows: 1. The administraction of 2-Pyrrolidone acetamide by subcutaneous injection (1. 5Gm/KG) , to the rats poisoned with 1% CO for 30 minutes and 60 minutes to observe the recovery time. ensued in the 'rapid recovery highly significantly compared with the control group. 2. Although no significance was found statistically, 2-Pyrrolidone acetamide administered group showed 56% and control group 44%; and this resulted 12% lowering of the fatality rate. 3. In the each experimental group administered 2Pyrrolidone acetamide by dose of 1. 5Gm/KG, 3.0 Gm/KG and 6,OGm/KG respectively before the exposure to 1% CO environment to observe the half fatality time, the moat significantly prolonged half fatality time was observed especially in the group of 3.0Gm/KG, dose although each of the experimental group revealed the significantly prolonged half fatality time compared to the control group. 4. However, more experimental and clinical studies have to be done to attain the definite conclusion on the therapeutic effectiveness of 2-Pyrrolidone acetamide administration combined with the hyperbaric oxygenation therapy in acute carbon monoxide poisoning.