만성간질환에 수반되는 신사구체병변에 관한 병리학적 검토와 인과관계

Abstract

In order to verify the immunologic mechanism in glornerulopathies following viral hepatitis in Korea. a light microscopic examination was carried out on 9 cases of glomerulopathy associated with histologically or clinically proven chronic and subsiding viral [tepatitis. Among the nine glomerular alterations were 6 cases of membrana-proliferative glomerulonephritis. 2 cases of membraneous glomerulopathy and 1 case of sclerosing glomerulonephritis probably resulting from mernbraneous glomerulopathy. Of the five liver needle biopsies 3 were chronic aggressive hepatitis, 1 subsiding acute viral hepatitis with residual fibrosis and micronodular cirrhosis of the liver. With relatively high incidence of membrano-proliferative glomerulonephritis among Koreans, seemingly reflected in part by the influence of serum hepatitis, especially with deposit of HBAg-Ab complexes, it is assumed that viral hepatitis is supposed to play an important role in the pathogenesis of glomerulonephritis in Korea. Also a discussion is made on that possibility of similar immune injury to the glomerular structures as shown in this investigation may replace the original concept of cirrhotic glomerulosclerosis.