S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 18 No.2 (1977)
만성간질환에 수반되는 신사구체병변에 관한 병리학적 검토와 인과관계
Glomerulopathies associated with Chronic Hepatitis ---Histological Reapprasal of Glomerular Lesions
- 김용일; 이정빈; 이환종
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.18 No.2, pp. 106-116
- In order to verify the immunologic mechanism in
glornerulopathies following viral hepatitis in Korea.
a light microscopic examination was carried out on 9
cases of glomerulopathy associated with histologically
or clinically proven chronic and subsiding viral [tepatitis.
Among the nine glomerular alterations were 6 cases
of membrana-proliferative glomerulonephritis. 2 cases of membraneous glomerulopathy and 1 case of sclerosing
glomerulonephritis probably resulting from mernbraneous
glomerulopathy. Of the five liver needle
biopsies 3 were chronic aggressive hepatitis, 1 subsiding
acute viral hepatitis with residual fibrosis and
micronodular cirrhosis of the liver.
With relatively high incidence of membrano-proliferative
glomerulonephritis among Koreans, seemingly
reflected in part by the influence of serum hepatitis,
especially with deposit of HBAg-Ab complexes, it is
assumed that viral hepatitis is supposed to play an
important role in the pathogenesis of glomerulonephritis
Also a discussion is made on that possibility of
similar immune injury to the glomerular structures as
shown in this investigation may replace the original
concept of cirrhotic glomerulosclerosis.