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사람태아의 비장 발육에 관한 형태학적 연구 : Light and Electron Microscopic Studies on the Intrauterine Development of Human Spleen

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서울대학교 의과대학
Seoul J Med, Vol.21 No.2, pp. 101-111
The spleens of human fetuses aged from 5 to 40 weeks were studied light and electron microscopically
to investigate the development of the white
pulp and the erythropoietic activities.
The splenic primodium was first seen at the 5th
week as a dense mass of mesenchymal cells on the
left side of the dorsal mesogastrium. At the 9th week
the spleen acquired it's characteristic form, and became
progressively converted into loose. spongy
reticular meshwork. At the 13th week there appeared
many developing vessels and wide blood sinuses in
the reticulum, and a number of erythrocytes and
erythroblasts were present in or out of vessels.
No significant level of erythropoiesis was observed
until the 12th week although a few of erythroblasts
were present in the capillaries of the splenic primodium.
At the 13th week many mitotic ligures of
erythroid cells were recognized, and the erythropoiesis
continued until the end of gestation, being
especially active during the middle third of fetal
The differentiation of the white pulp has begun
at the 13th week as the periarterial lymphatic sheath,
which consisted of circumferentially arranged reticular
cells and fibers around the central artery and
loaded with large and medium sized lymphocytes,
rnacrophages and a few erythrocytes. With advancing
age, the white pulp increased in its size, and
periarterial lymphatic sheath packed with small
lymphocytes more predominantly. The primary follicle
in the white pulp appeared first at the 21th week,
but no germinal center was observed throughout
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