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Comparative evaluation of nano-fibrous scaffolding for bone regeneration in critical size calvarial defects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, Kyung Mi | - |
dc.contributor.author | Chen, Victor J. | - |
dc.contributor.author | Jung, Hong-Moon | - |
dc.contributor.author | Kim, Tae-Il | - |
dc.contributor.author | Shin, Hong-In | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.contributor.author | Ma, Peter X. | - |
dc.date.accessioned | 2010-05-17T10:37:57Z | - |
dc.date.available | 2010-05-17T10:37:57Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | Tissue Eng Part A. 15, 2155 | en |
dc.identifier.issn | 1937-335X | - |
dc.identifier.uri | https://hdl.handle.net/10371/66610 | - |
dc.description.abstract | In a previous study we found that nanofibrous poly(l-lactic acid) (PLLA) scaffolds mimicking collagen fibers in
size were superior to solid-walled scaffolds in promoting osteoblast differentiation and bone formation in vitro. In this study we used an in vivo model to confirm the biological properties of nanofibrous PLLA scaffolds and to evaluate how effectively they support bone regeneration against solid-walled scaffolds. The scaffolds were implanted in critical-size defects made on rat calvarial bones. Compared with solid-walled scaffolds, nanofibrous scaffolds supported substantially more new bone tissue formation, which was confirmed by microcomputed tomography measurement and von Kossa staining. Goldners trichrome staining showed abundant collagen deposition in nanofibrous scaffolds but not in the control solid-walled scaffolds. The cells in these scaffolds were immuno-stained strongly for Runx2 and bone sialoprotein (BSP). In contrast, solid-walled scaffolds implanted in the defects were stained weakly with trichrome, Runx2, and BSP. These in vivo results demonstrate that nanofibrous architecture enhances osteoblast differentiation and bone formation. | en |
dc.description.sponsorship | The authors wish to acknowledge the financial support
from the Basic Research Program of the Korea Science & Engineering Foundation (R01-2005-000-106650 to K.M.W.), and the NIH-NIDCR&NIGMS of the United States (DE15384&17689 and GM75840 to P.X.M.). | en |
dc.language.iso | en | en |
dc.publisher | Mary Ann Liebert | en |
dc.title | Comparative evaluation of nano-fibrous scaffolding for bone regeneration in critical size calvarial defects | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 우경미 | - |
dc.contributor.AlternativeAuthor | 정홍문 | - |
dc.contributor.AlternativeAuthor | 김태일 | - |
dc.contributor.AlternativeAuthor | 신홍인 | - |
dc.contributor.AlternativeAuthor | 백정화 | - |
dc.contributor.AlternativeAuthor | 류현모 | - |
dc.identifier.doi | 10.1089/ten.tea.2008.0433 | - |
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