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Comparative evaluation of nano-fibrous scaffolding for bone regeneration in critical size calvarial defects

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dc.contributor.authorWoo, Kyung Mi-
dc.contributor.authorChen, Victor J.-
dc.contributor.authorJung, Hong-Moon-
dc.contributor.authorKim, Tae-Il-
dc.contributor.authorShin, Hong-In-
dc.contributor.authorBaek, Jeong-Hwa-
dc.contributor.authorRyoo, Hyun-Mo-
dc.contributor.authorMa, Peter X.-
dc.date.accessioned2010-05-17T10:37:57Z-
dc.date.available2010-05-17T10:37:57Z-
dc.date.issued2009-08-
dc.identifier.citationTissue Eng Part A. 15, 2155en
dc.identifier.issn1937-335X-
dc.identifier.urihttps://hdl.handle.net/10371/66610-
dc.description.abstractIn a previous study we found that nanofibrous poly(l-lactic acid) (PLLA) scaffolds mimicking collagen fibers in
size were superior to solid-walled scaffolds in promoting osteoblast differentiation and bone formation in vitro.
In this study we used an in vivo model to confirm the biological properties of nanofibrous PLLA scaffolds and to
evaluate how effectively they support bone regeneration against solid-walled scaffolds. The scaffolds were
implanted in critical-size defects made on rat calvarial bones. Compared with solid-walled scaffolds, nanofibrous
scaffolds supported substantially more new bone tissue formation, which was confirmed by microcomputed
tomography measurement and von Kossa staining. Goldners trichrome staining showed abundant
collagen deposition in nanofibrous scaffolds but not in the control solid-walled scaffolds. The cells in these
scaffolds were immuno-stained strongly for Runx2 and bone sialoprotein (BSP). In contrast, solid-walled scaffolds
implanted in the defects were stained weakly with trichrome, Runx2, and BSP. These in vivo results
demonstrate that nanofibrous architecture enhances osteoblast differentiation and bone formation.
en
dc.description.sponsorshipThe authors wish to acknowledge the financial support
from the Basic Research Program of the Korea Science &
Engineering Foundation (R01-2005-000-106650 to K.M.W.),
and the NIH-NIDCR&NIGMS of the United States
(DE15384&17689 and GM75840 to P.X.M.).
en
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.titleComparative evaluation of nano-fibrous scaffolding for bone regeneration in critical size calvarial defectsen
dc.typeArticleen
dc.contributor.AlternativeAuthor우경미-
dc.contributor.AlternativeAuthor정홍문-
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor신홍인-
dc.contributor.AlternativeAuthor백정화-
dc.contributor.AlternativeAuthor류현모-
dc.identifier.doi10.1089/ten.tea.2008.0433-
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