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Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Juyang | - |
dc.contributor.author | Choi, Sun Phil | - |
dc.contributor.author | La, Soojin | - |
dc.contributor.author | Seo, Jeong-Sun | - |
dc.contributor.author | Kim, Kack Kyun | - |
dc.contributor.author | Nam, Seok Hyun | - |
dc.contributor.author | Kwon, Byungsuk | - |
dc.date.accessioned | 2010-05-17T11:00:10Z | - |
dc.date.available | 2010-05-17T11:00:10Z | - |
dc.date.issued | 2003-12-31 | - |
dc.identifier.citation | Experimental and Molecular Medicine 2003;35(6):509-17 | en |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/66618 | - |
dc.description.abstract | 4-1BB, a transmembrane molecule, member of the
tumor necrosis factor receptor superfamily, is an im portant costim ulatory molecule in the immune response, plays a key role in the clonal expansion and survival of CD8+ T cells. In this study, we investigated 4-1BB regulation of CD4+ T cell responses using 4-1BB transgenic (TG) mice that constitutively expressed 4-1BB on mature T cells. We first showed that CD4+ T cells of 4-1BB TG mice had more sustained proliferative capacity in response to TCR/4-1BB stimulation in vitro compared to WT mice. Secondly, 4-1BB TG mice exhibited a more elevated contact hypersensitivity (CHS) response mediated by CD4+ Th1 cells due to more vigorous expansion of and apoptotic inhibition of CD4+ T cells. Finally, CD4+ T cells of 4-1BB TG mice had a heightened capacity for T cell prim ing. Overall, our results demonstrate the involvement of 4-1BB in CD4+ Th1 cell responses by regulating the clonal expansion and survival of CD4+ T cells as seen in CD8+ T cells. | en |
dc.description.sponsorship | This work was supported by Korea Research Foundation
Grant (KRF2000-D00285). | en |
dc.language.iso | en | en |
dc.publisher | Korean Society of Medical Biochemistry | en |
dc.subject | antigens, CD4 | en |
dc.subject | antigens, differentiation | en |
dc.subject | cytokines | en |
dc.subject | T lymphocyte | en |
dc.subject | T lymphocyte, hyper-inducer | en |
dc.subject | T lymphocyte subsets | en |
dc.title | Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김주양 | - |
dc.contributor.AlternativeAuthor | 최선필 | - |
dc.contributor.AlternativeAuthor | 라수진 | - |
dc.contributor.AlternativeAuthor | 서정선 | - |
dc.contributor.AlternativeAuthor | 김각균 | - |
dc.contributor.AlternativeAuthor | 남석현 | - |
dc.contributor.AlternativeAuthor | 권병석 | - |
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