급성 일산화탄소 중독이 백서 폐의 Clara세포에 미치는 영향에 관한 연구

Abstract

The authors report light microscopic and histochemical studies on the Clara cells of the terminal bronchioles in acute carbon monoxide poisoning rats. And, moreover, the morphologic features of the Clara cells and its population changes in the terminal bronchioles following short term exposure to carbon monoxide were observed. The nonciliated bronchiolar epithelial cells (the Clara cells) were responded to acute carbon monoxide poisoning as an acceleration of prominent extrusion of the apical caps and resulted in apocrine secretion into the terminal bronchiole as well as significant decrease of their numbers in lobal distribution by 45 to 60 minutes (peX') <0. 01). And by the 2 hours, there was slight degree of compensation, similar to that seen in tl e acute hypoxia caused a deficiency of pulmonary surfactant. The results of this study indicated that the Clara cells were actively metabolic and has apocrine secretory function, which might be related to the pulmonary surfactant mechanism. (This study was supported in part by the research grant(C.M.B. 74-332-5), the China Medical Board of New York. This paper was read at the 4th Asia Pacific Congress on Disease of the Chest.)