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Correlation between ciliary beat frequency and metachronal wave disorder using image analysis method

Cited 11 time in Web of Science Cited 12 time in Scopus
Authors
Yi, Won-Jin; Park, K.-S.; Lee, C.-H.; Rhee, C.-S.
Issue Date
2003-07
Publisher
Springer Verlag
Citation
Med. Biol. Eng. Comput., 41, 481-485
Keywords
Image analysis methodTwo-dimensional correlation mapPrincipal axis of inertiaCiliary beat frequencyMetachronal wave disorderCorrelation between CBF and MWD
Abstract
Ciliary beating and metachronal waves are fundamental to effective mucociliary transport. The ciliary beat frequencies (CBFs) and metachronal wave directions of multiple cilia beating in culture media were measured simultaneously using digital microscopic images. The degree of synchronisation between ciliary beats was determined by the correlation between ciliary signals at two different locations. The wave propagation directions of cilia were determined from a two-dimensional correlation map by a principal axis method. The standard deviation of measured wave directions in a region of interest was defined as a measure of metachronal wave disorder (MWD). Considerable variation was found in the beat frequencies and metachronal wave directions of cilia beating on epithelium. The pooled mean of MWDs was 23.4±8.8°, and the pooled mean of CBFs was 10.1±1.9 Hz on 120 cells from five healthy subjects. The means of the MWD and the CBF from subjects were highly correlated (correlation=−0.83). The higher the CBF, the lower the level of the MWD.
ISSN
0140-0118
Language
English
URI
https://hdl.handle.net/10371/66620
DOI
https://doi.org/10.1007/BF02348093
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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