S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Correlation of immunohistochemical characteristics of the craniomandibular joint with the degree of mandibular lengthening in rabbits
- Kim, Su-Gwan; Park, Ju-Cheol; Kang, Dong-Wan; Kim, Byung-Ock; Yoon, Jung-Hoon; Cho, Se-Inn; Choe, Han-Cheol; Bae, Chun-Sik
- Issue Date
- J Oral Maxillofac Surg 61:1189-1197
- Purpose: This study examined immunohistochemical changes in the craniomandibular joints of rabbits
after distraction osteogenesis following mandibular corticotomy.
Materials and Methods: The experimental animals (n 8) were divided into 3 groups that underwent
2, 3.5, and 5 mm of unilateral distraction osteogenesis (groups 1, 2, and 3, respectively). After
corticotomy of the left mandibular body and a 7-day healing period, a second operation was performed
to expose the device. Distraction was then performed at the rate of 0.5 mm/d. A 14-day consolidation
period was allowed after the distraction was complete. Changes in cartilage, osteoblast activity, and
osteoclast activity were then examined.
Results: The differentiation and proliferation of cartilage increased in groups 1 and 2, were highest in group
2, and decreased in group 3. Group 2 also showed the greatest increase in the width of the hypertrophic
chondrocyte layer. Relative to the control group, osteoclast activity was only somewhat higher in groups 1
and 2 but was significantly higher in group 3. Osteoblast activity was significantly higher in groups 1 and 2
than in the control group. However, the osteoblast activity in group 3 was slightly lower than that in group
2. At the time of unilateral mandibular distraction, no degenerative changes of the temporomandibular joint
were observed in groups 1 or 2, but bone resorption was observed in group 3.
Conclusions: The unilateral mandibular distraction of 2 or 3.5 mm was acceptable in that no degenerative
changes of the temporomandibular joint were observed on either the distraction or the nondistraction sides.
Five millimeters of distraction might be beyond physiologic limits.
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