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Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex

Cited 76 time in Web of Science Cited 80 time in Scopus
Authors
Choi, Se-Young; Chang, Jeff; Jiang, Bin; Seol, Geun-Hee; Min, Sun-Seek; Han, Jung-Soo; Shin, Hee-Sup; Gallagher, Michela; Kirkwood, Alfredo
Issue Date
2005-12
Publisher
Society for Neuroscience
Citation
Journal of Neuroscience 25:11433-11433
Keywords
adrenergiccholinergicglutamatergicLTDplasticityneuromodulation
Abstract
Mind/Brain Institute and Department of Neurosciences and 2Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, and 3National CRI Center for Calcium and Learning, Korea Institute of Science and Technology, Cheongryang, Seoul 136-791, Korea


Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of 1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP3). LTD was also impaired by intracellular application of PLC or IP3 receptor blockers, and it was absent in mice lacking PLC1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.
ISSN
0270-6474
Language
English
URI
http://hdl.handle.net/10371/66623
DOI
https://doi.org/10.1523/JNEUROSCI.4084-05.2005
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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