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Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells.

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dc.contributor.authorRyoo, Hyun-Mo-
dc.contributor.authorLee, Mi-Hye-
dc.contributor.authorKim, Youn-Jeong-
dc.date.accessioned2010-05-17T23:21:15Z-
dc.date.available2010-05-17T23:21:15Z-
dc.date.issued2006-01-
dc.identifier.citationGene 366, 51–57en
dc.identifier.issn0378-1119-
dc.identifier.urihttp://hdl.handle.net/10371/66624-
dc.description.abstractBone morphogenetic protein (BMP)-2 strongly induces bone formation. Introduction of the protein in muscle tissue results in ectopic bone formation. Similarly, BMP-2 treatment also stimulates the in vitro transdifferentiation of myogenic cells to osteogenic cells. The establishment of an in vitro model system has enabled the investigation of intracellular events including BMP receptor activation, BMP-2-induced R-Smad activation, and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2. Many reviews have addressed events downstream of BMP-receptor binding but few deal with molecular cascades involved in BMP-2-induced osteogenesis. We focus on critical molecular switches, especially transcription factors, and several kinase pathways involved in osteogenic differentiation.en
dc.description.sponsorshipThis study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Relectronic publicationlic of Korea (01-PJ1-PG1-01CH08-0001 and 01-PJ3-PG6-01GN11-0002).en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectBMP-2en
dc.subjectTGF-βen
dc.subjectSmaden
dc.subjectRunx2en
dc.subjectOsxen
dc.subjectDlx5en
dc.subjectMsx2en
dc.subjectOsteoblasten
dc.subjectDifferentiationen
dc.subjectBoneen
dc.titleCritical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells.en
dc.typeArticleen
dc.contributor.AlternativeAuthor류현모-
dc.contributor.AlternativeAuthor이미혜-
dc.contributor.AlternativeAuthor김윤정-
dc.identifier.doi10.1016/j.gene.2005.10.011-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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