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Mesenchymal stem cell-mediated functional tooth regeneration in swine

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dc.contributor.authorSeo, Byoung-Moo-
dc.contributor.authorSonoyama, Wataru-
dc.contributor.authorLiu, Yi-
dc.contributor.authorFang, Dianji-
dc.contributor.authorYamaza, Takayoshi-
dc.contributor.authorZhang, Chunmei-
dc.contributor.authorLiu, He-
dc.contributor.authorGronthos, Stan-
dc.contributor.authorWang, Cun-Yu-
dc.contributor.authorShi, Songtao-
dc.contributor.authorWang, Songlin-
dc.date.accessioned2010-05-17T23:34:58Z-
dc.date.available2010-05-17T23:34:58Z-
dc.date.issued2006-12-
dc.identifier.citationPlos One 1(1): e79en
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10371/66628-
dc.description.abstractMesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearanceen
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.titleMesenchymal stem cell-mediated functional tooth regeneration in swineen
dc.typeArticleen
dc.contributor.AlternativeAuthor서병무-
dc.identifier.doi10.1371/journal.pone.0000079-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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