S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 24 No.1 (1983)
정맥주사한 Li+의 부위별 조기분포상과 Na+ 및 K+의 혈중농도와 요중배설에 미치는 영향
Regional Distribution of Lithium Following Intravenous Injection and Its Effects on Plasma and Urine Electrolytes
- 박준; 김전
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.1, pp. 43-52
- This study was carried out to investigate the early
regional distribution of administered litbium and the
effects of lithium-load on the plasma concentration
and urinary excretion of Na" and K+.
After single intravenous injection of LiC! solution
(l. :;rnEq/kg), :;,1:;,30 and 60 min. samples were
taken from carotid artery, renal vein, jugular vein,
femoral vein and urinary bladder. Na", K+ and LiT
concentrations were measured together with the
determination of creatinine and osmolarity. From
these values several clearance data were calculated.
The following results were obtained:
1. Arterial Li" concentration measured at 5,15,30
and 60 min. after injection were 7. 9±0. 77, 6.2±
0.52, 4. 8±0. 46 and 3. 5±0. 40mEq/1 respectively.
Regional venous Li" concentrations decreased similarly
as time went by.
2. Arterio-venous Li" concentration differences in
jugular vein were -0. 4±0. 98, O.2±0. 45, -0.2±
0.16 and 0.1±0. 29 rnEq/l at 5,15,30 and 60 min.
respectively. So there was no arteria-venous differences
in jugular vein. 3. At 5 min., there was a significant difference of
2. 8±0. 43mEq/1 between arterial and venous Li"
concentration in femoral vein. But the differences
became smaller as time progressed and no significant
difference was noted by 60 min.
4. Li" concentrations of renal venous blood were
always significantly higher than those of arterial
5. In both control and Li group plasma Na"
concentrations decreased gradually as time went by.
But there was no significant differences between the
6. Plasma K+ concentration increased gradually
with the time lapse in both groups, but there was
no significant differences between control and Li
7. In control group. urine volume decreased from
the control value, O. 066±0. 026 nil/min/kg, progressively
to O. 031±0. 014 ml/min/kg by 30 min. On
the contrary, in Li group urine volume increased
from the control value, O. 066±0. 014 ml/rnin.ykg to
o, 186±0. 020, O. 086±0. 020 and O. 043±0. 006 ml/
min/kg at 5,15 and 30 min respectively.
8. Free water clearance were reversed from control
negative value to positive at 5 min. in both groups
but the increment was greater in Li group.
9. Li" clearances at 5, 15,30 min. were 0.64, 0.36,
0.10 ml/min/kg, respectively.
From the above results, it was concluded that the
administered Li" were distributed to all the body
tissue except brain. Also concluded that Li" were
filtered at glomerulus and reabsorbed at renal tubules
resulting the inhibition of electrogenic Na" reabsorption
initially and then followed by inhibition of
water reabsorption by chemical mechanism.