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Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling

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dc.contributor.authorJeon, Hye-Min-
dc.contributor.authorJin, Xun-
dc.contributor.authorLee, Joong-Seob-
dc.contributor.authorOh, Se-Yeong-
dc.contributor.authorSohn, Young-Woo-
dc.contributor.authorPark, Hyo-Jung-
dc.contributor.authorJoo, Kyeung Min-
dc.contributor.authorPark, Woong-Yang-
dc.contributor.authorNam, Do-Hyun-
dc.contributor.authorDePinho, Ronald A-
dc.contributor.authorChin, Lynda-
dc.contributor.authorKim, Hyunggee-
dc.date.accessioned2010-06-07-
dc.date.available2010-06-07-
dc.date.issued2008-08-05-
dc.identifier.citationGenes Dev. 22(15): 2028-2033en
dc.identifier.issn0890-9369 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18676808-
dc.identifier.urihttp://genesdev.cshlp.org/content/22/15/2028.full.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67471-
dc.description.abstractCellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules.en
dc.language.isoenen
dc.publisherCold Spring Harbor Laboratory Pressen
dc.subjectAnimalsen
dc.subjectAstrocytes/cytology/*physiologyen
dc.subjectCalcium-Binding Proteins/metabolismen
dc.subjectCell Culture Techniquesen
dc.subjectCell Line, Tumoren
dc.subject*Cell Transformation, Neoplasticen
dc.subjectCells, Cultureden
dc.subjectCerebral Cortex/cytologyen
dc.subjectCyclin E/*metabolismen
dc.subjectGlioblastoma/pathologyen
dc.subjectHumansen
dc.subjectInhibitor of Differentiation Proteins/*metabolismen
dc.subjectIntercellular Signaling Peptides and Proteins/metabolismen
dc.subjectMembrane Proteins/metabolismen
dc.subjectMiceen
dc.subjectMice, Knockouten
dc.subjectRNA, Messenger/metabolismen
dc.subjectReceptor, Notch1/genetics/*metabolismen
dc.subjectSignal Transduction/genetics/*physiologyen
dc.titleInhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signalingen
dc.typeArticleen
dc.contributor.AlternativeAuthor전혜민-
dc.contributor.AlternativeAuthor이종섭-
dc.contributor.AlternativeAuthor오세영-
dc.contributor.AlternativeAuthor손영우-
dc.contributor.AlternativeAuthor박효정-
dc.contributor.AlternativeAuthor주경민-
dc.contributor.AlternativeAuthor박웅양-
dc.contributor.AlternativeAuthor남도현-
dc.contributor.AlternativeAuthor김형기-
dc.identifier.doi10.1101/gad.1668708-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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