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Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Hye-Min | - |
dc.contributor.author | Jin, Xun | - |
dc.contributor.author | Lee, Joong-Seob | - |
dc.contributor.author | Oh, Se-Yeong | - |
dc.contributor.author | Sohn, Young-Woo | - |
dc.contributor.author | Park, Hyo-Jung | - |
dc.contributor.author | Joo, Kyeung Min | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Nam, Do-Hyun | - |
dc.contributor.author | DePinho, Ronald A | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2010-06-07 | - |
dc.date.available | 2010-06-07 | - |
dc.date.issued | 2008-08-05 | - |
dc.identifier.citation | Genes Dev. 22(15): 2028-2033 | en |
dc.identifier.issn | 0890-9369 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18676808 | - |
dc.identifier.uri | http://genesdev.cshlp.org/content/22/15/2028.full.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67471 | - |
dc.description.abstract | Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/-) astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules. | en |
dc.language.iso | en | en |
dc.publisher | Cold Spring Harbor Laboratory Press | en |
dc.subject | Animals | en |
dc.subject | Astrocytes/cytology/*physiology | en |
dc.subject | Calcium-Binding Proteins/metabolism | en |
dc.subject | Cell Culture Techniques | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cells, Cultured | en |
dc.subject | Cerebral Cortex/cytology | en |
dc.subject | Cyclin E/*metabolism | en |
dc.subject | Glioblastoma/pathology | en |
dc.subject | Humans | en |
dc.subject | Inhibitor of Differentiation Proteins/*metabolism | en |
dc.subject | Intercellular Signaling Peptides and Proteins/metabolism | en |
dc.subject | Membrane Proteins/metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Knockout | en |
dc.subject | RNA, Messenger/metabolism | en |
dc.subject | Receptor, Notch1/genetics/*metabolism | en |
dc.subject | Signal Transduction/genetics/*physiology | en |
dc.subject | Cell Transformation, Neoplastic | - |
dc.title | Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 전혜민 | - |
dc.contributor.AlternativeAuthor | 이종섭 | - |
dc.contributor.AlternativeAuthor | 오세영 | - |
dc.contributor.AlternativeAuthor | 손영우 | - |
dc.contributor.AlternativeAuthor | 박효정 | - |
dc.contributor.AlternativeAuthor | 주경민 | - |
dc.contributor.AlternativeAuthor | 박웅양 | - |
dc.contributor.AlternativeAuthor | 남도현 | - |
dc.contributor.AlternativeAuthor | 김형기 | - |
dc.identifier.doi | 10.1101/gad.1668708 | - |
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