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Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance

Cited 23 time in Web of Science Cited 27 time in Scopus
Authors
Choi, Sung Hee; Lee, You Jin; Park, Young Joo; Kim, Ki Woong; Lee, Eun Jung; Lim, Soo; Park, Do Joon; Kim, Sang Eun; Park, Kyong Soo; Jang, Hak C; Cho, Bo Youn
Issue Date
2008-04-03
Publisher
Endocrine Society
Citation
J Clin Endocrinol Metab. 93(6):2313-2318
Keywords
Age FactorsCardiovascular Diseases/etiologyFemaleGlucose/*metabolismGlucose Intolerance/bloodHumansHypothyroidism/blood/complicationsMaleObesity/*blood/complications/metabolismRetinol-Binding Proteins, Plasma/*metabolismRisk FactorsThyrotropin/*blood
Abstract
CONTEXT: Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear. OBJECTIVE: The objective of the study was to evaluate risk factors for CVD in elderly patients grouped according to thyroid function. DESIGN: 217 subjects (> or =65 yr old) were randomly selected from a population and allocated to a euthyroid group (n = 177) and an SCH group (n = 40) on the basis of plasma concentrations of TSH and free T(4). We included subjects with normal glucose tolerance by a 75-g oral glucose tolerance test and subjects with impaired fasting glucose. We measured anthropometric parameters, levels of fasting glucose and insulin, hemoglobin A(1c), adiponectin, RBP4, lipid profiles, total body fat content, and the area of sc and visceral fat. RESULTS: The SCH group had higher RBP4 levels than the euthyroid group, irrespective of body mass index and fat content. Subcutaneous and visceral fat areas and total body fat percentage did not differ between groups and were not correlated with RBP4 level. Other CVD risk factors did not differ between groups. RBP4 level was positively correlated with TSH level (r = 0.241, P = 0.001) after adjustment for age, sex, and body mass index. CONCLUSIONS: Plasma RBP4 levels were associated with SCH independent of obesity in elderly subjects with normal glucose tolerance, indicating that RBP4 level could be used as an index of CVD risk in SCH.
ISSN
0021-972X (Print)
Language
English
URI
http://jcem.endojournals.org/cgi/reprint/93/6/2313.pdf

https://hdl.handle.net/10371/67520
DOI
https://doi.org/10.1210/jc.2007-2536
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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