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Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy
DC Field | Value | Language |
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dc.contributor.author | Wang, Frank | - |
dc.contributor.author | Garza, Luis A | - |
dc.contributor.author | Cho, Soyun | - |
dc.contributor.author | Kafi, Reza | - |
dc.contributor.author | Hammerberg, Craig | - |
dc.contributor.author | Quan, Taihao | - |
dc.contributor.author | Hamilton, Ted | - |
dc.contributor.author | Mayes, Maureen | - |
dc.contributor.author | Ratanatharathorn, Voravit | - |
dc.contributor.author | Voorhees, John J | - |
dc.contributor.author | Fisher, Gary J | - |
dc.contributor.author | Kang, Sewon | - |
dc.date.accessioned | 2010-06-07T05:57:13Z | - |
dc.date.available | 2010-06-07T05:57:13Z | - |
dc.date.issued | 2008-07-23 | - |
dc.identifier.citation | Arch Dermatol. 2008;144(7):851-858 | en |
dc.identifier.issn | 1538-3652 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18645136 | - |
dc.identifier.uri | http://archderm.ama-assn.org/cgi/reprint/144/7/851.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67549 | - |
dc.description.abstract | OBJECTIVE: To investigate the efficacy, potential limitations, and biological mechanisms of UV-A1 phototherapy for skin sclerosis due to collagen deposition disorders. DESIGN: Before-and-after trial of UV-A1 irradiation of sclerotic skin; in vivo biochemical analyses after UV-A1 irradiation of normal skin. SETTING: Academic referral center. PARTICIPANTS: Patients with morphea/scleroderma or sclerodermoid graft-vs-host disease and volunteers without skin disease. Intervention Sclerotic skin was treated with high-dose (130 J/cm(2); n = 12) or medium-dose (65 J/cm(2); n = 6) UV-A1 phototherapy 3 times per week for 14 weeks; normal skin was treated with UV-A1 irradiation at various doses and frequencies, with biopsies performed afterwards. MAIN OUTCOME MEASURES: In sclerotic skin, induration was clinically assessed using a scoring scale. In normal skin, quantitative polymerase chain reaction was used to assess antifibrotic responses, defined as decreased type I and type III procollagen and increased matrix metalloproteinase levels. RESULTS: In patients with sclerotic skin treated with high-dose UV-A1 irradiation, clinical scores for induration modestly decreased. To investigate what factors prevented further improvement (ie, complete clearance), normal skin with light pigmentation was exposed to UV-A1 irradiation (70-150 J/cm(2)) and was assessed for antifibrotic responses. A single high-dose exposure (110-150 J/cm(2)) elicited substantial antifibrotic responses and induced skin darkening. This skin darkening attenuated responses to subsequent UV-A1 exposures and was dose dependent. Thus, to minimize skin darkening, additional patients with sclerotic skin were treated with medium-dose UV-A1 phototherapy, which was no less effective than high-dose therapy. CONCLUSION: Clinical responses of sclerotic skin to UV-A1 phototherapy were modest because of UV-A1-induced skin darkening, which is photoprotective and attenuates antifibrotic responses. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00129415. | en |
dc.language.iso | en | en |
dc.publisher | American Medical Association | en |
dc.subject | Collagen Type I/genetics/metabolism | en |
dc.subject | Collagen Type III/genetics/metabolism | en |
dc.subject | Dose-Response Relationship, Radiation | en |
dc.subject | Hyperpigmentation/*etiology/pathology | en |
dc.subject | Matrix Metalloproteinases/genetics/metabolism | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | RNA, Messenger/analysis | en |
dc.subject | Radiation Dosage | en |
dc.subject | Scleroderma, Localized/pathology/*radiotherapy | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Skin/*radiation effects | en |
dc.subject | Treatment Outcome | en |
dc.subject | Ultraviolet Rays | en |
dc.subject | Ultraviolet Therapy/*adverse effects | en |
dc.title | Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조소연 | - |
dc.contributor.AlternativeAuthor | 강세원 | - |
dc.identifier.doi | 10.1001/archderm.144.7.851 | - |
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