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Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Kyoung Soo | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Kim, Bo-Hyung | - |
dc.contributor.author | Kim, JaeWoo | - |
dc.contributor.author | Jeon, Ji-Young | - |
dc.contributor.author | Tae, Yu-Mi | - |
dc.contributor.author | Yi, SoJeong | - |
dc.contributor.author | Eum, SoYoung | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.date.accessioned | 2010-06-07T06:06:04Z | - |
dc.date.available | 2010-06-07T06:06:04Z | - |
dc.date.issued | 2008-08-30 | - |
dc.identifier.citation | Br J Clin Pharmacol. 2008; 66(5): 660-6 | en |
dc.identifier.issn | 1365-2125 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18754843 | - |
dc.identifier.uri | https://hdl.handle.net/10371/67552 | - |
dc.description.abstract | AIMS: The objectives were to evaluate the effect of CYP2D6 genetic polymorphism on the pharmacokinetics of flecainide, and also on the extent of drug interaction with paroxetine as a CYP2D6 inhibitor after a single oral administration in healthy subjects. METHODS: An open-label, two-period, single-sequence, cross-over study was performed in 21 healthy Korean male volunteers (seven for CYP2D6*1/*1 or *1/*2, group 1; seven for CYP2D6*1/*10, group 2; seven for CYP2D6*10/*10 or *10/*36, group 3). Subjects were administered 200 mg of flecainide on day 1. After a 7-day wash-out period, subjects were administered 20 mg of paroxetine from day 8 to 14, and 200 mg of flecainide on day 15. Blood sampling was performed up to 72 h after flecainide administration. RESULTS: Terminal elimination half-life and mean residence time (MRT) were significantly different among three genotype groups after a single oral administration of flecainide (P = 0.021, 0.011, respectively). Area under the concentration-time curve, terminal elimination half-life and MRT increased significantly after paroxetine co-administration only in groups 1 and 2. CONCLUSIONS: This study reports that the extent of drug interaction between flecainide and paroxetine is influenced by the CYP2D6*10 allele in healthy subjects, which is frequent in Asians. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Anti-Anxiety Agents/blood/*pharmacokinetics | en |
dc.subject | Anti-Arrhythmia Agents/blood/*pharmacokinetics | en |
dc.subject | Area Under Curve | en |
dc.subject | Cross-Over Studies | en |
dc.subject | Cytochrome P-450 CYP2D6/antagonists & inhibitors/*genetics | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Drug Interactions/genetics | en |
dc.subject | Flecainide/blood/*pharmacokinetics | en |
dc.subject | Genotype | en |
dc.subject | Half-Life | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Metabolic Clearance Rate | en |
dc.subject | Paroxetine/blood/*pharmacokinetics | en |
dc.subject | Statistics, Nonparametric | en |
dc.subject | Statistics, Nonparametric | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임경수 | - |
dc.contributor.AlternativeAuthor | 조주연 | - |
dc.contributor.AlternativeAuthor | 장인진 | - |
dc.contributor.AlternativeAuthor | 김보형 | - |
dc.contributor.AlternativeAuthor | 김재우 | - |
dc.contributor.AlternativeAuthor | 전지영 | - |
dc.contributor.AlternativeAuthor | 태유미 | - |
dc.contributor.AlternativeAuthor | 이소정 | - |
dc.contributor.AlternativeAuthor | 엄소영 | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.contributor.AlternativeAuthor | 유경상 | - |
dc.identifier.doi | 10.1111/j.1365-2125.2008.03267.x | - |
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