S-Space College of Natural Sciences (자연과학대학) Dept. of Biological Sciences (생명과학부) Journal Papers (저널논문_생명과학부)
BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers
- Lee, Yoo-kyung; Choi, Eunhee; Kim, Min A; Park, Pil-gu; Park, Noh-hyun; Lee, Hyunsook
- Issue Date
- Nature Publishing Group
- British Journal of Cancer 101: 504 – 510
- BACKGROUND: Epithelial ovarian cancer is one of the most lethal malignancies, and has a high recurrence rate. Thus, prognostic markers
for recurrence are crucial for the care of ovarian cancer. As ovarian cancers frequently exhibit chromosome instability, we aimed at
assessing the prognostic significance of two key mitotic kinases, BubR1 and Aurora A.
METHODS: We analysed paraffin-embedded tissue sections from 160 ovarian cancer patients whose clinical outcomes had been
tracked after first-line treatment.
RESULTS: The median recurrence-free survival in patients with a positive and negative expression of BubR1 was 27 and 83 months,
respectively (Po0.001). A positive BubR1 expression was also associated with advanced stage, serous histology and high grade.
In contrast, Aurora A immunostaining did not correlate with any of the clinical parameters analysed.
CONCLUSION: BubR1, but not Aurora A, is a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
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