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Pregnancy outcomes of different methods for multifetal pregnancy reduction: a comparative study

Cited 7 time in Web of Science Cited 11 time in Scopus
Authors

Lee, Jung Ryeol; Ku, Seung-Yup; Jee, Byung Chul; Suh, Chang Suk; Kim, Ki Chul; Kim, Seok Hyun

Issue Date
2008-02-28
Publisher
Korean Academy of Medical Sciences
Citation
J Korean Med Sci. 2008; 23(1): 111-6
Keywords
AdultFemaleHumansPotassium Chloride/therapeutic usePregnancyPregnancy Reduction, Multifetal/*methodsRetrospective StudiesPregnancy Outcome
Abstract
The purpose of this study was to evaluate the outcomes of various methods of multifetal pregnancy reduction (MFPR) and to determine which method produces better outcomes. One hundred and forty-eight patients with multiple pregnancies resulting from assisted reproduction programs and underwent MFPR were included. According to the use of potassium chloride (KCl), patients were divided into 'KCl', and 'non- KCl' groups, and based on gestational age at the time of procedures, patients were divided into 'Early' (before 8 weeks of gestation) and 'Late' (at 8 weeks or later) groups. Firstly, to clarify the effect of each component of MFPR procedure, data were analyzed between 'KCl' and 'non-KCl' groups, and between 'Early' and 'Late' groups with adjustments. Secondly, comparison between 'Early, non-KCl' and 'Late, KCl' groups was performed to evaluate the combinative effect of both components. Non-KCl groups showed a significantly higher take-home-baby rate, and lower risk of extreme prematurity and preterm premature rupture of membranes (PPROM) than KCl groups. Early groups showed a lower immediate loss rate than Late groups. As compared with 'Late, KCl' group, 'Early, non-KCl' group was superior in terms of immediate loss, pregnancy loss, take-home-baby, and PPROM rates. Our data suggest that the 'early, non-KCl' method may be a better option for MFPR.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18303209

https://hdl.handle.net/10371/67665
DOI
https://doi.org/10.3346/jkms.2008.23.1.111
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