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Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus

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dc.contributor.authorJin, Seon Mi-
dc.contributor.authorNoh, Chung Il-
dc.contributor.authorYang, Sei Won-
dc.contributor.authorBae, Eun Jung-
dc.contributor.authorShin, Choong Ho-
dc.contributor.authorChung, Hae Rim-
dc.contributor.authorKim, You Yeh-
dc.contributor.authorYun, Yong Soo-
dc.date.accessioned2010-06-14T07:28:40Z-
dc.date.available2010-06-14T07:28:40Z-
dc.date.issued2008-02-28-
dc.identifier.citationJ Korean Med Sci. 2008; 23(1): 77-82en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18303203-
dc.identifier.urihttps://hdl.handle.net/10371/67669-
dc.description.abstractWe examined whether alterations in vascular endothelial function and early structural changes in atherosclerosis are associated with microvascular complications in patients with type 1 diabetes mellitus (DM). Flow-mediated dilation (FMD) of the brachial artery and carotid intima-media thickness (IMT) measurement were performed in 70 young adults (aged 19 to 35 yr), 48 with type 1 DM, and 22 normal controls. Patients with diabetes had a lower peak FMD response (7.8+/-3.9 vs. 11.1+/-1.9%, p<0.001) and increased IMT (0.51+/-0.10 vs. 0.42+/-0.07 mm, p<0.001) compared with controls. Twenty (41.7%) of the patients had microvascular complications including neuropathy, nephropathy, or retinopathy. In these complicated diabetic patients, we found a lower FMD response (6.1+/-2.5 vs. 9.9+/-3.5%, p=0.001) compared with diabetics without microvascular complications. The presence of microvascular complications was also associated with older age and longer duration of the disease. However, no differences were observed in IMT, body size, blood pressure, HbA1c, C-reactive protein, low-density lipoprotein or high-density lipoprotein cholesterol levels between complicated and non-complicated patients. Endothelial dysfunction and early structural atherosclerotic changes are common manifestations in type 1 DM, and endothelial dysfunction is thought to be an early event in the atherosclerotic process and important in the pathogenesis of microvascular complications.en
dc.language.isoenen
dc.publisherKorean Academy of Medical Sciencesen
dc.subjectAdulten
dc.subjectDiabetes Mellitus, Type 1/*complicationsen
dc.subjectDiabetic Angiopathies/*etiologyen
dc.subjectEndothelium, Vascular/*physiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectTunica Intima/pathologyen
dc.subjectTunica Media/pathologyen
dc.subjectVasodilationen
dc.subjectMicrocirculation-
dc.titleEndothelial dysfunction and microvascular complications in type 1 diabetes mellitusen
dc.typeArticleen
dc.contributor.AlternativeAuthor진선미-
dc.contributor.AlternativeAuthor노청일-
dc.contributor.AlternativeAuthor양세원-
dc.contributor.AlternativeAuthor배은정-
dc.contributor.AlternativeAuthor신충호-
dc.contributor.AlternativeAuthor정해림-
dc.contributor.AlternativeAuthor김유예-
dc.contributor.AlternativeAuthor윤용수-
dc.identifier.doi10.3346/jkms.2008.23.1.77-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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