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Protective role of CYP1A1*2A in the development of multiple myeloma

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dc.contributor.authorKang, Seong-Ho-
dc.contributor.authorKim, Tae Young-
dc.contributor.authorKim, Ho Young-
dc.contributor.authorYoon, Jong-Hyun-
dc.contributor.authorCho, Han-Ik-
dc.contributor.authorYoon, Sung Soo-
dc.contributor.authorKang, Dae Hee-
dc.contributor.authorSuh, Cheol Won-
dc.contributor.authorLee, Jae Hoon-
dc.contributor.authorLee, Dong Soon-
dc.date.accessioned2010-06-22T04:54:31Z-
dc.date.available2010-06-22T04:54:31Z-
dc.date.issued2008-02-21-
dc.identifier.citationActa Haematol. 2008;119(1):60-64en
dc.identifier.issn1421-9662 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18285692-
dc.identifier.urihttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000117572&Ausgabe=234243&ProduktNr=223829&filename=000117572.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67754-
dc.description.abstractWe had previously reported the association of the NQO1*2/*2 polymorphism with a decreased risk for multiple myeloma (MM) in Koreans (odds ratio, OR, 0.24; 95% confidence interval, CI, 0.01-0.68). The associations of polymorphisms of other metabolizing enzymes (CYP1A1, GSTM1 and GSTT1) with the MM risk were investigated in 116 Korean MM patients and 176 Korean controls using TaqMan allelic discrimination and multiplex polymerase chain reaction. The ORs for CYP1A1*1/*2A and CYP1A1*1/*2B genotypes were 0.43 (95% CI, 0.19-0.98) and 0.51 (95% CI, 0.26-0.98), respectively, which was significantly associated with a decreased MM risk. With regard to CYP1A1 alleles, the OR for the CYP1A1*2A allele was 0.57 (95% CI, 0.326-0.995), which was also significantly associated with a decreased MM risk. However, null types of GSTM1 and GSTT1 polymorphisms were not associated with the MM risk. These results were different from those of a previous report on Caucasians which suggested the association of the GSTT1 polymorphism with an increased MM risk and no association of CYP1A1 with the MM risk. The associations of polymorphisms of metabolizing enzymes with the risk for MM differed between Koreans and Caucasians, suggesting an ethnic variation in the susceptibility to MM.en
dc.language.isoenen
dc.publisherKargeren
dc.subjectAllelesen
dc.subjectBase Sequenceen
dc.subjectCytochrome P-450 CYP1A1/*geneticsen
dc.subjectDNA Primersen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectMultiple Myeloma/*enzymology/*genetics/pathologyen
dc.subjectPolymerase Chain Reactionen
dc.subjectPolymorphism, Single Nucleotide-
dc.titleProtective role of CYP1A1*2A in the development of multiple myelomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor강성호-
dc.contributor.AlternativeAuthor김태영-
dc.contributor.AlternativeAuthor김호영-
dc.contributor.AlternativeAuthor윤종현-
dc.contributor.AlternativeAuthor조한익-
dc.contributor.AlternativeAuthor윤성수-
dc.contributor.AlternativeAuthor강대희-
dc.contributor.AlternativeAuthor서철원-
dc.contributor.AlternativeAuthor이재훈-
dc.contributor.AlternativeAuthor이동순-
dc.identifier.doi10.1159/000117572-
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