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Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Mee Hyang | - |
dc.contributor.author | Kim, Soonhag | - |
dc.contributor.author | Hwang, Do Won | - |
dc.contributor.author | Ko, Hae Young | - |
dc.contributor.author | Kim, Young Ha | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.date.accessioned | 2010-06-25T05:27:49Z | - |
dc.date.available | 2010-06-25T05:27:49Z | - |
dc.date.issued | 2008-04-16 | - |
dc.identifier.citation | FEBS Journal 275(10), 2605-2516 | en |
dc.identifier.issn | 1742-464X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18410378 | - |
dc.identifier.uri | https://hdl.handle.net/10371/67794 | - |
dc.description.abstract | Generally, the 3'-end of the duplex microRNA (miR) precursor (pre-miR) is known to be stable in vivo and serve as a mature form of miR. However, both the 3'-end (miR9) and 5'-end (miR9*) of a brain-specific miR9 have been shown to function biologically in brain development. In this study, real-time PCR analysis and in vitro/in vivo bioluminescent imaging demonstrated that the upstream region of a primary miR9-1 (pri-miR9-1) can be used to monitor the highly expressed pattern of endogenous pri-miR9-1 during neurogenesis, and that the Luciferase reporter gene can image the unequal expression patterns of miR9 and miR9* seen during the neuronal differentiation of P19 cells. This demonstrates that our bioimaging system can be used to study the participation of miRs in the regulation of neuronal differentiation. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Animals | en |
dc.subject | Base Sequence | en |
dc.subject | Cell Differentiation/*physiology | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Genes, Reporter | en |
dc.subject | Mice | en |
dc.subject | Mice, Nude | en |
dc.subject | MicroRNAs/genetics/*metabolism | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Neurons/cytology/*physiology | en |
dc.subject | Brain/cytology/embryology | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.title | Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 고미향 | - |
dc.contributor.AlternativeAuthor | 김순학 | - |
dc.contributor.AlternativeAuthor | 황도원 | - |
dc.contributor.AlternativeAuthor | 고해영 | - |
dc.contributor.AlternativeAuthor | 김영하 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.identifier.doi | 10.1111/j.1742-4658.2008.06408.x | - |
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