Browse

Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer

Cited 22 time in Web of Science Cited 28 time in Scopus
Authors
Lee, Ho-Young; Chung, June-Key; Jeong, Jae Min; Lee, Dong Soo; Kim, Dong Gyu; Jung, Hee Won; Lee, Myung Chul
Issue Date
2008-06-07
Publisher
Springer Verlag
Citation
Ann Nucl Med. 2008;22(4):281-6
Keywords
AgedBrain Neoplasms/*radionuclide imaging/secondaryCarcinoma, Non-Small-Cell Lung/*radionuclide imaging/secondaryCarcinoma, Small Cell/*radionuclide imaging/secondaryFemaleFluorodeoxyglucose F18/*pharmacokineticsHumansLung Neoplasms/pathology/radionuclide imagingMaleMiddle AgedNeoplasm Staging*Positron-Emission TomographyRadiopharmaceuticals/pharmacokineticsSensitivity and SpecificityWhole-Body Counting
Abstract
OBJECTIVE: We compared the F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings of brain metastasis between patients with non-small-cell lung cancer (NSCLC) and small cell lung cancer (SCLC). METHODS: A whole-body FDG and a brain PET were performed in 48 patients (31 men, 17 women; 57 +/- 9 years, 42 NSCLC, 6 SCLC), who had brain metastasis on magnetic resonance (MR). All primary lung lesions were detected by FDG-PET and confirmed pathologically. We analyzed the PET findings, lesion sizes, and the pathological result of primary lung cancer. RESULTS: Of the 48 patients, 31 (64.6%) showed hypermetabolic lesions on FDG-PET of the brain image, and 14 (29.2%) showed hypometabolic lesions. Three patients (6.3%) had both hypermetabolic and hypometabolic lesions. On the lesion-based analysis, 74 lesions (67.3%) showed hypermetabolism on FDG-PET, and 36 lesions (32.7%) showed hypometabolism. All primary lung lesions were hypermetabolic on FDG-PET. When the FDG findings of metastatic brain lesions were analyzed with the pathological types of primary lung cancer, NSCLC was more frequently associated with hypermetabolic metastatic brain lesions than SCLC (80% and 26.7%, respectively, P < 0.01). On comparing the sizes of metastatic lesions between SCLC (1.3 +/- 1.2 cm) and NSCLC (1.8 +/- 1.2 cm), lesions of <1 cm were more frequent in SCLC than in NSCLC (P = 0.012). But no significant relationship was found between the size and PET finding of metastatic lesion (P = 0.412). CONCLUSIONS: Even when the primary lesion of lung cancer showed hypermetabolism in FDG-PET, FDG accumulation in metastatic brain lesions was variable. One-third of brain metastases from lung cancer showed hypometabolism. NSCLC was more frequently associated with hypermetabolic metastatic brain lesions than SCLC. The PET findings of brain lesions were affected not only by the size of lesion but also by its biological characteristics.
ISSN
0914-7187 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18535878

http://www.springerlink.com/content/d09662594271u8j6/fulltext.pdf

https://hdl.handle.net/10371/67801
DOI
https://doi.org/10.1007/s12149-007-0104-1
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse