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Erythropoietin reduces epileptogenic processes following status epilepticus

Cited 71 time in Web of Science Cited 76 time in Scopus
Authors
Chu, Kon; Jung, Keun-Hwa; Lee, Soon-Tae; Kim, Jin-Hee; Kang, Kyung-Muk; Kim, Hyun-Kyung; Lim, Jae-Sung; Park, Hee-Kwon; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu
Issue Date
2008-05-16
Publisher
Wiley-Blackwell
Citation
Epilepsia. 49(10):1723-1732
Keywords
Analysis of VarianceAnimalsAntigens, CD11b/metabolismBrain/pathologyBromodeoxyuridine/metabolismCapillary Permeability/drug effects/physiologyCell Death/drug effectsDisease Models, AnimalElectroencephalography/methodsErythropoietin, Recombinant/*therapeutic useFluorescein/diagnostic useGene Expression Regulation/drug effectsHomeodomain Proteins/metabolismMaleNeurons/drug effectsPhosphopyruvate Hydratase/metabolismPilocarpineRatsRats, Sprague-DawleyStatistics, NonparametricStatus Epilepticus/chemically induced/*drugtherapy/pathology/*physiopathologyTumor Suppressor Proteins/metabolism
Abstract
PURPOSE: Erythropoietin (EPO) has neuron and astroglial protective effects via reduction of tissue-injuring molecules such as reactive oxygen species, glutamate, inflammatory cytokines, and other damaging molecules. Although EPO may constitute an effective therapeutic modality in cases of epileptic insult, no study has been performed on the effects of exogenous EPO on the chronic seizure formation. In this study, we attempted to investigate if EPO could modulate the altered microenvironment in the epileptic rat brain. METHODS: Morphological changes in the hippocampi of rats subjected to lithium-pilocarpine-induced status epilepticus (SE) were examined with respect to neuronal loss, inflammation, blood-brain barrier (BBB) leakage, and cell genesis. Spontaneous recurrent seizures (SRSs) were investigated by long-term video-EEG monitoring. RESULTS: EPO receptor (EPOR) was found to be increased in the hippocampus after SE. Administered EPO prevented, during the latent period following SE, BBB leakage, neuronal death, and microglia activation in the dentate hilus, CA1, and CA3, and inhibited the generation of ectopic granule cells in the hilus and new glia in CA1. Moreover, EPO reduced the risk of SRS development. DISCUSSION: These findings suggest that EPO has a potential therapeutic role in the setting of acute epileptic insults.
ISSN
1528-1167 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18479396

http://hdl.handle.net/10371/67833
DOI
https://doi.org/10.1111/j.1528-1167.2008.01644.x
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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