S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Erythropoietin reduces epileptogenic processes following status epilepticus
- Chu, Kon; Jung, Keun-Hwa; Lee, Soon-Tae; Kim, Jin-Hee; Kang, Kyung-Muk; Kim, Hyun-Kyung; Lim, Jae-Sung; Park, Hee-Kwon; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu
- Issue Date
- Epilepsia. 49(10):1723-1732
- Analysis of Variance; Animals; Antigens, CD11b/metabolism; Brain/pathology; Bromodeoxyuridine/metabolism; Capillary Permeability/drug effects/physiology; Cell Death/drug effects; Disease Models, Animal; Electroencephalography/methods; Erythropoietin, Recombinant/*therapeutic use; Fluorescein/diagnostic use; Gene Expression Regulation/drug effects; Homeodomain Proteins/metabolism; Male; Neurons/drug effects; Phosphopyruvate Hydratase/metabolism; Pilocarpine; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Status Epilepticus/chemically induced/*drug; therapy/pathology/*physiopathology; Tumor Suppressor Proteins/metabolism
- PURPOSE: Erythropoietin (EPO) has neuron and astroglial protective effects via reduction of tissue-injuring molecules such as reactive oxygen species, glutamate, inflammatory cytokines, and other damaging molecules. Although EPO may constitute an effective therapeutic modality in cases of epileptic insult, no study has been performed on the effects of exogenous EPO on the chronic seizure formation. In this study, we attempted to investigate if EPO could modulate the altered microenvironment in the epileptic rat brain. METHODS: Morphological changes in the hippocampi of rats subjected to lithium-pilocarpine-induced status epilepticus (SE) were examined with respect to neuronal loss, inflammation, blood-brain barrier (BBB) leakage, and cell genesis. Spontaneous recurrent seizures (SRSs) were investigated by long-term video-EEG monitoring. RESULTS: EPO receptor (EPOR) was found to be increased in the hippocampus after SE. Administered EPO prevented, during the latent period following SE, BBB leakage, neuronal death, and microglia activation in the dentate hilus, CA1, and CA3, and inhibited the generation of ectopic granule cells in the hilus and new glia in CA1. Moreover, EPO reduced the risk of SRS development. DISCUSSION: These findings suggest that EPO has a potential therapeutic role in the setting of acute epileptic insults.
- 1528-1167 (Electronic)
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