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Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier
Cited 442 time in
Web of Science
Cited 480 time in Scopus
- Authors
- Issue Date
- 2008-06-07
- Publisher
- American Heart Association
- Citation
- Stroke. 2008;39(8):2396-2399
- Keywords
- Arterial Occlusive Diseases/*epidemiology/etiology/therapy ; Cerebral Arteries ; Humans ; Risk Factors ; Stroke/*epidemiology/etiology/therapy ; World Health
- Abstract
- BACKGROUND AND PURPOSE: Large artery intracranial occlusive disease (LAICOD) is a common and important stroke subtype. In this commentary, we review key epidemiological aspects of LAICOD. SUMMARY OF REVIEW: LAICOD has emerged as the most common stroke subtype worldwide and is associated with a high risk of recurrent stroke. Hypotheses have been proposed to explain causation, which include such factors as traditional cardiovascular risk factors, high blood volume states, and genetic abnormalities. Approaches to treatment such as antithrombotic therapies, revascularization procedures, and counterpulsation devices hold promise. CONCLUSIONS: LAICOD poses a major stroke problem worldwide and is likely the most common stroke subtype. The etiology and treatment of this disorder remain poorly defined. International collaborations are needed to pool collective knowledge and develop definitive studies to better understand causation and treatment of LAICOD.
- ISSN
- 1524-4628 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18535283
http://stroke.ahajournals.org/cgi/reprint/39/8/2396.pdf
https://hdl.handle.net/10371/67839
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