Publications

Detailed Information

Evolution of VX2 carcinoma in rabbit tibia: magnetic resonance imaging with pathologic correlation

Cited 10 time in Web of Science Cited 9 time in Scopus
Authors

Choi, Jung-Ah; Kang, Eun Young; Kim, Han Kyeom; Song, In Chan; Kim, Young I I; Kang, Heung Sik

Issue Date
2008-03-04
Publisher
Elsevier
Citation
Clin Imaging. 2008;32(2):128-35
Keywords
AnimalsBone Neoplasms/*pathology/*secondaryNecrosisNeoplasm TransplantationNeoplasms, Experimental/pathologyRabbitsTibia/*pathologyMagnetic Resonance Imaging
Abstract
OBJECTIVE: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. MATERIALS AND METHODS: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. RESULTS: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). CONCLUSION: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor.
ISSN
0899-7071 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18313577

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T5C-4S0MXC6-9-5&_cdi=4999&_user=168665&_orig=search&_coverDate=04%2F30%2F2008&_sk=999679997&view=c&wchp=dGLbVzW-zSkzV&md5=ed80d1510858b9aea413fa5c6793a917&ie=/sdarticle.pdf

https://hdl.handle.net/10371/67846
DOI
https://doi.org/10.1016/j.clinimag.2007.08.021
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share