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Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model

Cited 50 time in Web of Science Cited 52 time in Scopus
Authors
Lim, Soo; Yoon, Ji Won; Choi, Sung Hee; Cho, Bong Jun; Kim, Jun Tae; Chang, Ha Soon; Park, Ho Seon; Park, Kyong Soo; Lee, Hong Kyu; Kim, Young-Bum; Jang, Hak Chul
Issue Date
2008-12-09
Publisher
Elsevier
Citation
Metabolism. 2009;58(1):8-15
Keywords
Abdominal Fat/anatomy & histology/drug effectsAnimalsBlood Glucose/metabolismBody Weight/*drug effectsCholesterol/bloodGlucose/*metabolismGlucose Tolerance TestGlucose Transporter Type 4/metabolismInsulin/bloodInsulin Resistance/physiologyLiver/anatomy & histology/drug effects/metabolismMaleMuscle, Skeletal/drug effectsObesity/blood/*drug therapy/*metabolismOrgan Size/drug effectsPPAR gamma/metabolismPhosphorylationPolysaccharides/*pharmacologyProtein Kinases/metabolismRatsRats, Inbred OLETFTriglycerides/blood
Abstract
Extracts of ginseng species show antihyperglycemic activity. We evaluated the antihyperglycemic and antiobesity effects of ginsam, a component of Panax ginseng produced by vinegar extraction, which is enriched in the ginsenoside Rg3. Otsuka Long-Evans Tokushima Fatty rats, an obese insulin-resistant rat model, were assigned into 1 of 3 groups (n = 8 each): controls (isotonic sodium chloride solution, 5 mL/d), rats given 300 mg/(kg d) ginsam, and rats given 500 mg/(kg d) ginsam. An intraperitoneal 2-hour glucose tolerance test was performed at the end of the 6-week treatment. After 8 weeks, body and liver weights, visceral fat measured by computed tomography, and fasting glucose and insulin concentrations and lipid profiles were recorded. Insulin-resistant rats treated with ginsam had lower fasting and postprandial glucose concentrations compared with vehicle-treated rats. Importantly, overall glucose excursion during the intraperitoneal 2-hour glucose tolerance test decreased by 21.5% (P < .01) in the treated rats, indicating improved glucose tolerance. Plasma insulin concentration was significantly lower in ginsam-treated rats. These changes may be related to increased glucose transporter 4 expression in skeletal muscle. Interestingly, when the data from both ginsam-treated groups were combined, body weight was 60% lower in the ginsam-treated rats than in the controls (P < .01). Liver weight and serum alanine aminotransferase concentrations were also lower in the ginsam-treated rats. These effects were associated with increased peroxisome proliferator-activated receptor gamma expression and adenosine monophosphate-activated protein kinase phosphorylation in liver and muscle. Our data suggest that ginsam has distinct beneficial effects on glucose metabolism and body weight control in an obese animal model of insulin resistance by changing the expression of genes involved in glucose and fatty acid metabolism.
ISSN
1532-8600 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19059525

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WN4-4V34H9X-6-9&_cdi=6952&_user=168665&_orig=search&_coverDate=01%2F31%2F2009&_sk=999419998&view=c&wchp=dGLzVlz-zSkzV&md5=686c54949ab3512e8003190ba27251d9&ie=/sdarticle.pdf

https://hdl.handle.net/10371/67855
DOI
https://doi.org/10.1016/j.metabol.2008.07.027
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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