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Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
DC Field | Value | Language |
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dc.contributor.author | Ng, Maggie C Y | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Oh, Bermseok | - |
dc.contributor.author | Tam, Claudia H T | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Lam, Vincent K L | - |
dc.contributor.author | Ma, Ronald C W | - |
dc.contributor.author | So, Wing Yee | - |
dc.contributor.author | Cho, Yoon Shin | - |
dc.contributor.author | Kim, Hyung-Lae | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Chan, Juliana C N | - |
dc.contributor.author | Cho, Nam H | - |
dc.date.accessioned | 2010-06-28 | - |
dc.date.available | 2010-06-28 | - |
dc.date.issued | 2008-05-13 | - |
dc.identifier.citation | Diabetes. 57(8):2226-2233 | en |
dc.identifier.issn | 1939-327X (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18469204 | - |
dc.identifier.uri | http://diabetes.diabetesjournals.org/content/57/8/2226.full.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67868 | - |
dc.description.abstract | OBJECTIVE: Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed TCF7L2 as the major type 2 diabetes gene to date in Europeans. However, the implications of these genes in Asians are unclear. RESEARCH DESIGN AND METHODS: We studied 13 associated single nucleotide polymorphisms from these genes in 3,041 patients with type 2 diabetes and 3,678 control subjects of Asian ancestry from Hong Kong and Korea. RESULTS: We confirmed the associations of TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, and FTO with risk for type 2 diabetes, with odds ratios ranging from 1.13 to 1.35 (1.3 x 10(-12) < P(unadjusted) < 0.016). In addition, the A allele of rs8050136 at FTO was associated with increased BMI in the control subjects (P(unadjusted) = 0.008). However, we did not observe significant association of any genetic variants with surrogate measures of insulin secretion or insulin sensitivity indexes in a subset of 2,662 control subjects. Compared with subjects carrying zero, one, or two risk alleles, each additional risk allele was associated with 17% increased risk, and there was an up to 3.3-fold increased risk for type 2 diabetes in those carrying eight or more risk alleles. Despite most of the effect sizes being similar between Asians and Europeans in the meta-analyses, the ethnic differences in risk allele frequencies in most of these genes lead to variable attributable risks in these two populations. CONCLUSIONS: Our findings support the important but differential contribution of these genetic variants to type 2 diabetes and obesity in Asians compared with Europeans. | en |
dc.language.iso | en | en |
dc.publisher | American Diabetes Association | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Asian Continental Ancestry Group/*genetics | en |
dc.subject | Cation Transport Proteins/genetics | en |
dc.subject | Cyclin-Dependent Kinase 5/genetics | en |
dc.subject | Cyclin-Dependent Kinase Inhibitor p15/genetics | en |
dc.subject | Cyclin-Dependent Kinase Inhibitor p16/genetics | en |
dc.subject | Diabetes Mellitus, Type 2/ethnology/*genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease/ethnology/genetics | en |
dc.subject | Genotype | en |
dc.subject | Homeodomain Proteins/genetics | en |
dc.subject | Hong Kong/epidemiology | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Obesity/ethnology/*genetics | en |
dc.subject | RNA-Binding Proteins/genetics | en |
dc.subject | TCF Transcription Factors/genetics | en |
dc.subject | Transcription Factors/genetics | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 오범석 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 조윤신 | - |
dc.contributor.AlternativeAuthor | 김형래 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.identifier.doi | 10.2337/db07-1583 | - |
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