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Lack of association between apolipoprotein E polymorphism and vascular dementia in Koreans

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Authors
Kim, Ki Woong; Youn, Jong-Chul; Han, Moon-Ku; Paik, Nam Jong; Lee, Tae Joo; Park, Joon Hyuk; Lee, Seok Bum; Choo, Il Han; Lee, Dong Young; Jhoo, Jin Hyeong; Woo, Jong Inn
Issue Date
2008-02-22
Publisher
SAGE Publications
Citation
J Geriatr Psychiatry Neurol. 2008;21(1):12-17
Keywords
AgedAged, 80 and overAllelesAlzheimer Disease/*geneticsApolipoproteins E/*geneticsAsian Continental Ancestry Group/*geneticsDementia, Vascular/*ethnology/*geneticsFemaleGenetic Predisposition to DiseaseGenotypeHumansMalePolymorphism, Genetic/*genetics
Abstract
To investigate an association of vascular dementia (VD) with the apolipoprotein E (APOE) polymorphism, the APOE polymorphism of 100 VD patients, 100 age- and gender-matched Alzheimer disease (AD) patients, and 200 age- and gender-matched nondemented control (NC) subjects was genotyped. The distribution of APOE polymorphism was compared. Neither the APOE epsilon4 allele nor the APOE epsilon2 allele was more prevalent in the VD patients compared with the NC subjects (P > .1 by the chi 2 test), which was the case when both men and women were analyzed separately (P > .1 by the chi2 test) and when young patients (75 years old or less) and old patients (more than 75 years old) were analyzed separately (P > .1 by the chi2 test). The estimated statistical power was over 0.80 when the odds ratios (OR) for VD conferred to the APOE epsilon4 are assumed to be higher than 2.2 and the type I error probability is set at 0.05, which is much higher than the power of the previous studies on the VD/APOE association. In conclusion, the results suggested that APOE epsilon4 allele does not confer the risk for VD, and even if it does, it does so very modestly.
ISSN
0891-9887 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18287165

http://jgp.sagepub.com/cgi/reprint/21/1/12.pdf

https://hdl.handle.net/10371/67881
DOI
https://doi.org/10.1177/0891988707311028
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College of Medicine/School of Medicine (의과대학/대학원)Rehabilitation Medicine (재활의학전공)Journal Papers (저널논문_재활의학전공)
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