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Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eun-Kyung | - |
dc.contributor.author | Chung, June-Key | - |
dc.contributor.author | Lim, Il Han | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Lee, Myung Chul | - |
dc.contributor.author | Cho, Bo Youn | - |
dc.date.accessioned | 2010-06-28T04:58:01Z | - |
dc.date.available | 2010-06-28T04:58:01Z | - |
dc.date.issued | 2008-09-10 | - |
dc.identifier.citation | Eur J Nucl Med Mol Imaging. 2009;36(2):172-9 | en |
dc.identifier.issn | 1619-7089 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18779963 | - |
dc.identifier.uri | http://www.springerlink.com/content/w1j7l7255527q287/fulltext.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67914 | - |
dc.description.abstract | PURPOSE: Serum Tg and I-131 WBS have been used to detect recurrent and metastatic thyroid cancers postoperatively. Tg is known to be more sensitive than I-131 WBS, and therefore, false-negative WBS cases with elevated Tg levels are frequently found. However, the clinical characteristics of false-negative Tg cases with positive WBS have not been clarified. MATERIALS AND METHODS: The authors evaluated 824 postoperative patients with differentiated thyroid carcinoma who underwent post-ablation/therapy I-131 WBS. Tg negativity was defined as a Tg level of < or = 2 ng/mL without TgAb under thyroid-stimulating hormone stimulation. Remission, recurrence, and metastasis were confirmed using pathologic or clinically findings. RESULTS: Fifty-two patients (6.3%) with functioning metastasis and negativity for TgAb were Tg-negative and posttherapy I-131 WBS-positive (TgN group), and 128 patients with functioning metastases were Tg positive and WBS positive (TgP group). The TgN group consisted of 45 cases of cervical/mediastinal lymph node metastases (86.5%) and seven cases of distant metastasis to lung or bone by follow-up WBS. The TgN group demonstrated significantly higher profiles of regional involvement than the TgP group (P < 0.029). In 47 patients in the TgN group, metastatic uptake disappeared in 33, ameliorated in four, and persisted in ten during follow-up. CONCLUSIONS: A significant number of differentiated thyroid cancer patients were Tg-/TgAb-negative despite a positive WBS finding. Cervical and mediastinal lymph nodes were predominant sites of metastasis in the TgN group. WBS should be undertaken routinely as a complementary modality to detect functioning recurrence and metastasis regardless of serum Tg results. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | False Negative Reactions | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Iodine Radioisotopes/diagnostic use/therapeutic use | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Recurrence | en |
dc.subject | Thyroglobulin/*blood | en |
dc.subject | Thyroid Neoplasms/blood/*diagnosis/*secondary/therapy | en |
dc.subject | Whole Body Imaging | en |
dc.title | Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박은경 | - |
dc.contributor.AlternativeAuthor | 정준기 | - |
dc.contributor.AlternativeAuthor | 임일한 | - |
dc.contributor.AlternativeAuthor | 박도준 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 이명철 | - |
dc.contributor.AlternativeAuthor | 조보윤 | - |
dc.identifier.doi | 10.1007/s00259-008-0912-0 | - |
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