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Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans

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dc.contributor.authorPark, Eun-Kyung-
dc.contributor.authorChung, June-Key-
dc.contributor.authorLim, Il Han-
dc.contributor.authorPark, Do Joon-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorLee, Myung Chul-
dc.contributor.authorCho, Bo Youn-
dc.date.accessioned2010-06-28T04:58:01Z-
dc.date.available2010-06-28T04:58:01Z-
dc.date.issued2008-09-10-
dc.identifier.citationEur J Nucl Med Mol Imaging. 2009;36(2):172-9en
dc.identifier.issn1619-7089 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18779963-
dc.identifier.urihttp://www.springerlink.com/content/w1j7l7255527q287/fulltext.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67914-
dc.description.abstractPURPOSE: Serum Tg and I-131 WBS have been used to detect recurrent and metastatic thyroid cancers postoperatively. Tg is known to be more sensitive than I-131 WBS, and therefore, false-negative WBS cases with elevated Tg levels are frequently found. However, the clinical characteristics of false-negative Tg cases with positive WBS have not been clarified. MATERIALS AND METHODS: The authors evaluated 824 postoperative patients with differentiated thyroid carcinoma who underwent post-ablation/therapy I-131 WBS. Tg negativity was defined as a Tg level of < or = 2 ng/mL without TgAb under thyroid-stimulating hormone stimulation. Remission, recurrence, and metastasis were confirmed using pathologic or clinically findings. RESULTS: Fifty-two patients (6.3%) with functioning metastasis and negativity for TgAb were Tg-negative and posttherapy I-131 WBS-positive (TgN group), and 128 patients with functioning metastases were Tg positive and WBS positive (TgP group). The TgN group consisted of 45 cases of cervical/mediastinal lymph node metastases (86.5%) and seven cases of distant metastasis to lung or bone by follow-up WBS. The TgN group demonstrated significantly higher profiles of regional involvement than the TgP group (P < 0.029). In 47 patients in the TgN group, metastatic uptake disappeared in 33, ameliorated in four, and persisted in ten during follow-up. CONCLUSIONS: A significant number of differentiated thyroid cancer patients were Tg-/TgAb-negative despite a positive WBS finding. Cervical and mediastinal lymph nodes were predominant sites of metastasis in the TgN group. WBS should be undertaken routinely as a complementary modality to detect functioning recurrence and metastasis regardless of serum Tg results.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdulten
dc.subjectFalse Negative Reactionsen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectIodine Radioisotopes/diagnostic use/therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRecurrenceen
dc.subjectThyroglobulin/*blooden
dc.subjectThyroid Neoplasms/blood/*diagnosis/*secondary/therapyen
dc.subjectWhole Body Imagingen
dc.titleRecurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scansen
dc.typeArticleen
dc.contributor.AlternativeAuthor박은경-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor임일한-
dc.contributor.AlternativeAuthor박도준-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor이명철-
dc.contributor.AlternativeAuthor조보윤-
dc.identifier.doi10.1007/s00259-008-0912-0-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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