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Galectin-3: a useful biomarker for differential diagnosis of brain tumors

Cited 20 time in Web of Science Cited 24 time in Scopus
Authors
Park, Sung-Hye; Min, Hye Sook; Kim, Bomi; Myung, Jaekyung; Paek, Sun Ha
Issue Date
2008-04-04
Publisher
Wiley-Blackwell
Citation
Neuropathology. 2008; 28(5): 497-506
Keywords
Brain Neoplasms/*diagnosis/*metabolismDiagnosis, DifferentialGalectin 3/*biosynthesis/*diagnostic useHumansImmunohistochemistryTumor Markers, Biological/*analysis
Abstract
Galectin-3 (gal-3) is a 31 kDa beta-galactoside-binding lectin that is immunohistochemically expressed in macrophages, lymphocytes, and endothelial cells, and also in some neoplastic cells. Gal-3's expression in and significance to brain tumors has not been fully addressed. Here, we investigated its immunohistochemical expression in 409 cases of surgically resected primary brain tumors, including various glioneuronal tumors, pituitary adenomas, meningiomas and Schwannomas, among others. In normal brain tissues, gal-3 was robustly expressed in normal astrocytes, endothelial cells and macrophages. It showed consistent and diffuse positivity in 100% of the pilocytic astrocytomas, pleomorphic xanthoastrocytomas (PXA), Schwannomas, meningiomas, capillary hemangioblastomas, as well as in ependymomas, but it was completely negative in the diffuse astrocytomas, anaplastic astrocytomas, both low- and high-grades of the oligodendrogliomas, central neurocytomas, and medulloblastomas. Definitely positive but heterogeneous expression was found in various tumors including subependymal giant cell astrocytomas (SEGA), classic glioblastoma multiforme, anaplastic oligoastrocytomas, CNS primitive neuroectodermal tumors (CNS PNETs), and hemangiopericytomas. Eighty percent of small cell glioblstomas were completely negative, but 20% showed heterogeneous positivity for gal-3. Focal positivity for gal-3 was also found in dysembryoplastic neuroepithelial tumors (DNTs) and gangliogliomas, in which the positive cells were the astrocytic component. On the basis of our immunohistochemical data in conjunction with previous reports, we therefore conclude that gal-3 is differentially expressed in various brain tumors, and thereby, is a helpful biomarker in making differential diagnoses, especially in cases where a morphological diagnosis is controversial.
ISSN
1440-1789 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18384511

https://hdl.handle.net/10371/67941
DOI
https://doi.org/10.1111/j.1440-1789.2008.00909.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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