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Prostate-specific antigen and prostate volume in Korean men with spinal cord injury: a case-control study

Cited 8 time in Web of Science Cited 8 time in Scopus
Authors
Shim, H B; Kim, Y D; Jung, T Y; Lee, J K; Ku, J H
Issue Date
2007-03-28
Publisher
Nature Publishing Group
Citation
Spinal Cord. 2008; 46(1): 11-15
Keywords
Age FactorsAgedAged, 80 and overAsian Continental Ancestry GroupAutonomic Nervous System/physiopathologyBiological Markers/bloodCase-Control StudiesComorbidityCross-Sectional StudiesGonadotropins/bloodHumansKorea/epidemiologyMaleMiddle AgedOrgan SizeProspective StudiesProstate/innervation/secretion/*ultrasonographyProstate-Specific Antigen/*blood/secretionSpinal Cord Injuries/*blood/*epidemiology/physiopathologyStatistics as TopicTestosterone/blood/secretion
Abstract
STUDY DESIGN: Prospective, cross-sectional, case-control study. SETTING: Outpatient department in Seoul, Korea. OBJECTIVES: To assess prostate volume and serum prostate-specific antigen (PSA) levels in Korean men with spinal cord injury (SCI). METHODS: A total of 31 SCI patients with ages ranging between 45 and 81 years old (median age, 58 years) were studied. Thirty-one age-matched individuals without SCI were enrolled in the study as controls. We tested PSA levels and performed transrectal ultrasonographies on all enrolled patients. Of the patients with SCI, 20 were evaluated for testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels. RESULTS: Serum PSA levels and prostate volume parameters in the two groups had similar values: the median (5th-95th percentiles) serum PSA level was 1.56 ng/ml (0.12-9.77) for SCI patients and 1.04 ng/ml (0.50-2.98) for controls (P=0.481), whereas the median (5th-95th percentiles) prostate volume was 18.33 ml (10.16-76.78) for SCI patients and 20.80 ml (14.23-41.22) for controls (P=0.072). No significant differences were found when serum PSA levels and prostate volumes were compared according to SCI patient injury characteristics. Testosterone levels were lower than the normal range in 7 SCI patients (35%), LH was higher than the normal range in 10 SCI patients (20%), and FSH was higher than the normal range in eight SCI patients (40%). We observed an age-related increase in FSH levels (r=0.634, P=0.004), although hormone levels did not correlate with serum PSA levels and prostate volume parameters. CONCLUSIONS: According to our results, serum PSA levels and prostate volume in Korean SCI patients are not different from those in uninjured men and are not affected by injury characteristics.
ISSN
1362-4393 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17387315

http://www.nature.com/sc/journal/v46/n1/pdf/3102051a.pdf

https://hdl.handle.net/10371/67944
DOI
https://doi.org/10.1038/sj.sc.3102051
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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