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Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination

Cited 19 time in Web of Science Cited 23 time in Scopus
Authors
Jeong, Chang Wook; Lim, Dae Jung; Son, Hwancheol; Lee, Sang Eun; Jeong, Hyeon
Issue Date
2008-03-26
Publisher
Karger
Citation
Urol Int. 2008;80(2):157-161
Keywords
Adrenergic alpha-Antagonists/*therapeutic useAdultAnti-Bacterial Agents/*therapeutic useDoxazosin/*therapeutic useDrug Therapy, CombinationHumansMaleMiddle AgedOfloxacin/*therapeutic useProspective StudiesProstatitis/*drug therapy
Abstract
INTRODUCTION: We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome. PATIENTS AND METHODS: Men with a NIH diagnosis of category III chronic prostatitis/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29). RESULTS: The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001). CONCLUSIONS: For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.
ISSN
1423-0399 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18362485

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000112606&Ausgabe=234231&ProduktNr=224282&filename=000112606.pdf

http://hdl.handle.net/10371/67950
DOI
https://doi.org/10.1159/000112606
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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