Publications
Detailed Information
MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, S O | - |
dc.contributor.author | Jeon, Y K | - |
dc.contributor.author | Paik, J H | - |
dc.contributor.author | Kim, W Y | - |
dc.contributor.author | Kim, Y A | - |
dc.contributor.author | Kim, J E | - |
dc.contributor.author | Kim, C W | - |
dc.date.accessioned | 2010-06-30T01:30:49Z | - |
dc.date.available | 2010-06-30T01:30:49Z | - |
dc.date.issued | 2008-08-30 | - |
dc.identifier.citation | Histopathology. 2008; 53(2): 205-217 | en |
dc.identifier.issn | 1365-2559 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18752503 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68026 | - |
dc.description.abstract | AIMS: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes in adult DLBCLs to evaluate their clinicopathological features and prognostic implications. METHODS AND RESULTS: Gene status was examined using fluorescence in situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%, five of 145), and ICN was observed in 11.7% (17 of 145), more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. CONCLUSIONS: Analyses of MYC and Bcl-2 status, i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and determine therapeutic strategies. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | B-Lymphocytes/pathology | en |
dc.subject | Female | en |
dc.subject | Germinal Center/*pathology | en |
dc.subject | Humans | en |
dc.subject | In Situ Hybridization, Fluorescence | en |
dc.subject | Lymphoma, Large B-Cell, Diffuse/*diagnosis/*genetics/mortality/pathology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Predictive Value of Tests | en |
dc.subject | Prognosis | en |
dc.subject | Proto-Oncogene Proteins c-bcl-2/genetics | en |
dc.subject | Proto-Oncogene Proteins c-bcl-6/genetics | en |
dc.subject | Proto-Oncogene Proteins c-myc/*genetics | en |
dc.subject | Gene Dosage | - |
dc.subject | Translocation, Genetic | - |
dc.title | MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1365-2559.2008.03076.x | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.