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Interleukin-12 p40 gene (IL12B) polymorphisms and the risk of cervical cancer in Korean women

Cited 35 time in Web of Science Cited 38 time in Scopus
Authors
Han, Seung-Su; Cho, Eun-Young; Lee, Taek Sang; Kim, Jae Weon; Park, Noh-Hyun; Song, Yong-Sang; Kim, Jung Gu; Lee, Hyo-Pyo; Kang, Soon-Beom
Issue Date
2008-03-28
Publisher
Elsevier
Citation
Eur J Obstet Gynecol Reprod Biol. 2008;140(1):71-75
Keywords
Case-Control StudiesFemaleGene FrequencyGenetic Predisposition to Disease/*geneticsHaplotypes/geneticsHumansInterleukin-12 Subunit p40/*geneticsKoreaMiddle AgedPolymorphism, Single Nucleotide/*geneticsUterine Cervical Neoplasms/*genetics
Abstract
OBJECTIVE: The aim of this study was to investigate whether IL12B polymorphisms might be associated with increased risk and invasiveness of cervical cancer in Korean women. STUDY DESIGN: Peripheral blood samples from patients with invasive cervical cancer (n=154) and non-cancer controls (n=191) were used to detect three biallelic IL12B polymorphisms at IVS2 -912, IVS4 +314, 3'UTR +1188 sites by performing SNaPshot assay. Allelic frequencies, genotype distributions, and haplotype patterns in the case group were compared with those in the control group. The relationships between these polymorphisms and cancer invasiveness were also evaluated by collating the clinicopathologic parameters including FIGO stage, lymph node status, histologic type, and parametrial invasion. The used analytic methods are chi-square test and logistic regression analysis. RESULTS: Allelic frequencies of cases (G, 0.853; A, 0.147) were not significantly different from controls (G, 0.796; A, 0.204) in IVS2 -912G/A SNP (P=0.054). GG genotype of IVS2 -912G/A SNP showed increased risk for cervical cancer compared with AA genotype (P=0.040). The IVS2 -912G:IVS4+314A haplotype, IVS2 -912G:IVS4 +314A:3'UTR +1188A haplotype, and IVS2 -912G:IVS4 +314A:3'UTR +1188C haplotype were also significantly associated with increased risk for cervical cancer. A subgroup analysis of the clinicopathologic parameters in cancer group also showed that there is no significant association between IL12B polymorphisms and cervical cancer invasiveness. CONCLUSIONS: This study suggests that IVS2 -912GG genotype and IVS2 -912G:IVS4 +314A haplotype of IL12B gene are associated with increased risk for cervical cancer in Korean women.
ISSN
0301-2115 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18367309

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T69-4S4J6RH-1-1&_cdi=5025&_user=168665&_orig=search&_coverDate=09%2F30%2F2008&_sk=998599998&view=c&wchp=dGLbVzW-zSkzV&md5=0333a7b9cb21fe7c19f9b4d2342f6f9e&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68033
DOI
https://doi.org/10.1016/j.ejogrb.2008.02.007
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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