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Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2
DC Field | Value | Language |
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dc.contributor.author | Han, S S | - |
dc.contributor.author | No, J H | - |
dc.contributor.author | Jeon, Y T | - |
dc.contributor.author | Kim, J W | - |
dc.contributor.author | Park, N H | - |
dc.contributor.author | Song, Y S | - |
dc.contributor.author | Kang, S B | - |
dc.contributor.author | Lee, H P | - |
dc.date.accessioned | 2010-06-30T03:14:02Z | - |
dc.date.available | 2010-06-30T03:14:02Z | - |
dc.date.issued | 2008-01-10 | - |
dc.identifier.citation | Hum Reprod. 2008;23(3):525-529 | en |
dc.identifier.issn | 1460-2350 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18182398 | - |
dc.identifier.uri | http://humrep.oxfordjournals.org/cgi/reprint/23/3/525.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68035 | - |
dc.description.abstract | BACKGROUND: Many studies have shown that a polymorphism (G870A) in cyclin D1 (CCND1) is associated with carcinogenesis in a variety of cancers. Our aim was to determine if an association exists between the CCND1 G870A polymorphism and uterine leiomyoma in Korean women. METHODS: Blood samples of 331 cases and 204 controls aged 47.4 +/- 7.6 and 46.8 +/- 10.4 years (mean +/- SD), respectively, were collected. CCND1 genotyping was determined by PCR and restriction fragment length polymorphism. RESULTS: Allelic frequencies of cases (A, 0.53; G, 0.47) were not significantly different from those of controls (A, 0.49; G, 0.51) (P = 0.22). After adjustment for menarche age and BMI, multivariate logistic regression analysis showed that the AA genotype was not associated with increased risk for uterine leiomyoma [odds ratio (OR) = 1.38, 95% confidence interval (CI); 0.85-2.26, P = 0.19]. However, in stratification analysis of cases and controls with BMI >25 kg/m(2), allelic frequencies of cases (A, 0.56; G, 0.44) were significantly different from controls (A, 0.36; G, 0.64) (P = 0.005), and the AA genotype was associated with increased risk for uterine leiomyoma (OR = 3.61, 95% CI; 1.02-12.73, P = 0.046). Furthermore, the OR for AA compared with combined GG and AG genotypes was 3.16 (95% CI 1.01-9.92, P = 0.048). CONCLUSIONS: The A allele and AA genotype of CCND1 G870A polymorphism have a significant association with an increased risk of the uterine leiomyoma in obese Korean women. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Asian Continental Ancestry Group | en |
dc.subject | Cyclins/*genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Leiomyoma/*genetics | en |
dc.subject | Menarche | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Uterine Neoplasms/*genetics | en |
dc.subject | Body Mass Index | - |
dc.title | Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2 | en |
dc.type | Article | en |
dc.identifier.doi | 10.1093/humrep/dem407 | - |
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