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Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2

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dc.contributor.authorHan, S S-
dc.contributor.authorNo, J H-
dc.contributor.authorJeon, Y T-
dc.contributor.authorKim, J W-
dc.contributor.authorPark, N H-
dc.contributor.authorSong, Y S-
dc.contributor.authorKang, S B-
dc.contributor.authorLee, H P-
dc.date.accessioned2010-06-30T03:14:02Z-
dc.date.available2010-06-30T03:14:02Z-
dc.date.issued2008-01-10-
dc.identifier.citationHum Reprod. 2008;23(3):525-529en
dc.identifier.issn1460-2350 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18182398-
dc.identifier.urihttp://humrep.oxfordjournals.org/cgi/reprint/23/3/525.pdf-
dc.identifier.urihttp://hdl.handle.net/10371/68035-
dc.description.abstractBACKGROUND: Many studies have shown that a polymorphism (G870A) in cyclin D1 (CCND1) is associated with carcinogenesis in a variety of cancers. Our aim was to determine if an association exists between the CCND1 G870A polymorphism and uterine leiomyoma in Korean women. METHODS: Blood samples of 331 cases and 204 controls aged 47.4 +/- 7.6 and 46.8 +/- 10.4 years (mean +/- SD), respectively, were collected. CCND1 genotyping was determined by PCR and restriction fragment length polymorphism. RESULTS: Allelic frequencies of cases (A, 0.53; G, 0.47) were not significantly different from those of controls (A, 0.49; G, 0.51) (P = 0.22). After adjustment for menarche age and BMI, multivariate logistic regression analysis showed that the AA genotype was not associated with increased risk for uterine leiomyoma [odds ratio (OR) = 1.38, 95% confidence interval (CI); 0.85-2.26, P = 0.19]. However, in stratification analysis of cases and controls with BMI >25 kg/m(2), allelic frequencies of cases (A, 0.56; G, 0.44) were significantly different from controls (A, 0.36; G, 0.64) (P = 0.005), and the AA genotype was associated with increased risk for uterine leiomyoma (OR = 3.61, 95% CI; 1.02-12.73, P = 0.046). Furthermore, the OR for AA compared with combined GG and AG genotypes was 3.16 (95% CI 1.01-9.92, P = 0.048). CONCLUSIONS: The A allele and AA genotype of CCND1 G870A polymorphism have a significant association with an increased risk of the uterine leiomyoma in obese Korean women.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAsian Continental Ancestry Groupen
dc.subject*Body Mass Indexen
dc.subjectCyclins/*geneticsen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectLeiomyoma/*geneticsen
dc.subjectMenarcheen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Geneticen
dc.subjectUterine Neoplasms/*geneticsen
dc.titleAssociation of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2en
dc.typeArticleen
dc.identifier.doi10.1093/humrep/dem407-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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