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Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Choung, Seon Ha | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Yoon, Sang Ho | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.date.accessioned | 2010-06-30T06:18:46Z | - |
dc.date.available | 2010-06-30T06:18:46Z | - |
dc.date.issued | 2008-01-15 | - |
dc.identifier.citation | Fertil Steril. 2008;90(6):2318-2323 | en |
dc.identifier.issn | 1556-5653 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18191848 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6K-4RKDHV6-D-1&_cdi=5033&_user=168665&_orig=search&_coverDate=12%2F31%2F2008&_sk=999099993&view=c&wchp=dGLbVzW-zSkWz&md5=c4d62c64f6d713d5fc579fabdbd7bb5e&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68051 | - |
dc.description.abstract | OBJECTIVE: To evaluate the role of the androgen receptor (AR) gene CAG repeat in women with polycystic ovary syndrome (PCOS). DESIGN: Case control study. SETTING: University department of obstetrics and gynecology. PATIENT(S): Women with (n = 114) or without (n = 205) PCOS. INTERVENTION(S): Peripheral blood sampling was done for DNA analysis and serum hormone measurements. MAIN OUTCOME MEASURE(S): CAG repeat length and serum androgen levels. RESULT(S): No statistically significant CAG repeat length differences were found between patients and controls. We conducted a detailed analysis after dividing PCOS patients according to their free testosterone levels. The high free testosterone group had a statistically significantly longer mean biallelic average (24.0 +/- 2.0 vs. 23.0 +/- 1.5), short (22.5 +/- 1.8 vs. 21.7 +/- 1.9), and long (25.5 +/- 2.9 vs. 24.4 +/- 1.9) allelic lengths than the normal free testosterone group. In PCOS patients, a statistically significant correlation was found between biallelic average length and free testosterone concentration, either unadjusted or after adjustment. CONCLUSION(S): The AR gene CAG repeat polymorphism may contribute to the serum concentration of free testosterone in PCOS patients. A subset of PCOS patients with relatively longer CAG repeats (less AR activity) tended to show a higher serum androgen concentration. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Phenotype | en |
dc.subject | Polycystic Ovary Syndrome/*genetics/metabolism | en |
dc.subject | Receptors, Androgen/*genetics/metabolism | en |
dc.subject | Testosterone/blood | en |
dc.subject | Young Adult | en |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Trinucleotide Repeats | - |
dc.title | Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김진주 | - |
dc.contributor.AlternativeAuthor | 정선하 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 윤상호 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1016/j.fertnstert.2007.10.030 | - |
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