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The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ja Yeon | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Kim, Jung Gu | - |
dc.date.accessioned | 2010-06-30T06:24:56Z | - |
dc.date.available | 2010-06-30T06:24:56Z | - |
dc.date.issued | 2007-12-11 | - |
dc.identifier.citation | Eur J Obstet Gynecol Reprod Biol. 2008;139(1):106-110 | en |
dc.identifier.issn | 0301-2115 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18069114 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T69-4RB5GPB-2-4&_cdi=5025&_user=168665&_orig=search&_coverDate=07%2F31%2F2008&_sk=998609998&view=c&wchp=dGLzVzz-zSkzS&md5=5d2ebec02268a0c7428c8f3b2ec8e84d&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68052 | - |
dc.description.abstract | OBJECTIVES: To investigate the associations between endometriosis and the G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1), and serum and peritoneal fluid MCP-1 levels in Korean women. STUDY DESIGN: The G(-2518)A polymorphism of MCP-1 was analyzed by restriction fragment length polymorphism in 105 women with and in 101 women without endometriosis. Serum and peritoneal fluid MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The genotype frequencies of the MCP-1 G (-2518)A polymorphism were GG 36.9%, AG 52.9%, and AA 10.2%. MCP-1 genotype frequencies and serum and peritoneal fluid MCP-1 levels were similar in those with or without endometriosis and were not dependent on disease stage. A significant correlation was found between serum and peritoneal fluid levels of MCP-1. However, no differences were found between MCP-1 genotypes in terms of serum and peritoneal fluid MCP-1 levels. CONCLUSIONS: Serum and peritoneal fluid MCP-1 levels and the G (-2518)A MCP-1 polymorphism were found not to be associated with endometriosis in Korean women. | en |
dc.description.sponsorship | This work was supported by the Korea Research
Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2005-041-E00224). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Ascitic Fluid/chemistry | en |
dc.subject | Case-Control Studies | en |
dc.subject | Chemokine CCL2/blood/*genetics | en |
dc.subject | Endometriosis/*genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Polymorphism, Single Nucleotide/*genetics | en |
dc.subject | Uterine Diseases/*genetics | en |
dc.title | The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김자연 | - |
dc.contributor.AlternativeAuthor | 김훈 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 김중구 | - |
dc.identifier.doi | 10.1016/j.ejogrb.2007.10.009 | - |
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