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Association of tumor necrosis factor-{alpha} gene polymorphisms with advanced stage endometriosis

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dc.contributor.authorLee, Gyoung Hoon-
dc.contributor.authorChoi, Young Min-
dc.contributor.authorKim, Sung Hoon-
dc.contributor.authorHong, Min A-
dc.contributor.authorOh, Sung Tack-
dc.contributor.authorLim, Young Taik-
dc.contributor.authorMoon, Shin Yong-
dc.date.accessioned2010-06-30T07:56:26Z-
dc.date.available2010-06-30T07:56:26Z-
dc.date.issued2008-02-15-
dc.identifier.citationHum Reprod. 2008;23(4):977-981en
dc.identifier.issn1460-2350 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18272527-
dc.identifier.urihttp://humrep.oxfordjournals.org/cgi/reprint/23/4/977.pdf-
dc.identifier.urihttp://hdl.handle.net/10371/68073-
dc.description.abstractBACKGROUND: This study was performed to investigate whether specific haplotypes and several single nucleotide polymorphisms in the promoter region of the tumor necrosis factor (TNF)-alpha gene are associated with the risk of advanced stage endometriosis in a Korean population. METHODS: This study comprised women with (n = 246) or without (n = 248) endometriosis. The TNF:g.[-1031T > C], TNF:g.[-863C > A] and TNF:g.[-857C > T] polymorphism in the TNF-alpha gene were assessed by PCR-restriction fragment length polymorphism analysis, which utilized digestion by BbsI, HypCH4IV and HypCH4IV restriction enzymes, respectively. In silico haplotypes were deduced by using the Haploview version 3.32. RESULTS: The genotype distribution of TNF:g.[-1031T > C] was significantly different between total endometriosis patients and the controls (T/T of 56.9 versus 60.1%, T/C of 35.4 versus 37.5% and C/C of 7.7 versus 2.4%, respectively, P = 0.027). This difference at the TNF:g.[-1031T > C] tends to increase in Stage IV endometriosis (P = 0.01). However, there was no difference in the TNF:g.[-863C > A] and TNF:g.[-857C > T] site between the two groups. Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine Stages III and IV, genotype differences were not found. The CC homozygote at TNF:g.-863 was more frequently found in the controls than Non-CC group (P = 0.04; odds ratio = 0.67; 95% confidence interval = 0.45-0.98). All haplotypes and diplotypes, deduced by in silico analysis, showed no association with subgroups or controls. CONCLUSIONS: Our results suggest that the genotype frequencies at the TNF:g.[-1031T > C] and the TNF:g.[-863C > A] sites may be associated with advanced stage endometriosis in the Korean population.en
dc.description.sponsorshipThis study was supported by a grant (01-PJ10-PG6-
01GN13-0002) from the Korea Health 21 R&D Project, Ministry
of Health & Welfare, Republic of Korea.
en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subjectAdulten
dc.subjectCase-Control Studiesen
dc.subjectEndometriosis/*geneticsen
dc.subjectFemaleen
dc.subjectHaplotypesen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectRisk Factorsen
dc.subjectSeverity of Illness Indexen
dc.subjectTumor Necrosis Factor-alpha/*geneticsen
dc.titleAssociation of tumor necrosis factor-{alpha} gene polymorphisms with advanced stage endometriosisen
dc.typeArticleen
dc.contributor.AlternativeAuthor이경훈-
dc.contributor.AlternativeAuthor최영민-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor홍민아-
dc.contributor.AlternativeAuthor오성택-
dc.contributor.AlternativeAuthor임영택-
dc.contributor.AlternativeAuthor문신용-
dc.identifier.doi10.1093/humrep/den016-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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