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Follicular fluid anti-Mullerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles

Cited 30 time in Web of Science Cited 33 time in Scopus
Authors
Lee, Jung Ryeol; Kim, Seok Hyun; Kim, Sun Mie; Jee, Byung Chul; Ku, Seung-Yup; Suh, Chang Suk; Choi, Young Min; Kim, Jung Gu; Moon, Shin Yong
Issue Date
2008-02-06
Publisher
Elsevier
Citation
Fertil Steril. 2008;89(4):860-867
Keywords
AdultAge FactorsAnti-Mullerian Hormone/blood/*metabolismBiological Markers/metabolismChorionic Gonadotropin/administration & dosageDose-Response Relationship, DrugDrug Administration ScheduleEmbryo ImplantationEstradiol/metabolismFemaleFertility Agents, Female/*administration & dosageFertilization in VitroFollicular Fluid/*drug effects/metabolismGonadotropin-Releasing Hormone/administration & dosage/agonists/*analogs & derivatives/antagonists & inhibitorsHormone Antagonists/*administration & dosageHumansInfertility, Female/therapyInhibins/blood/*metabolismOocyte RetrievalOvulation Induction/*methodsPregnancyPregnancy RateProgesterone/metabolismProspective StudiesTreatment OutcomeTriptorelin/*administration & dosage
Abstract
OBJECTIVE: To compare follicular fluid (FF) anti-Mullerian hormone (AMH) and inhibin B concentrations for GnRH agonist (GnRH-a) and GnRH antagonist cycles and to determine the correlations between FF AMH or inhibin B concentrations and controlled ovarian hyperstimulation (COH) outcomes. DESIGN: Prospective comparative study. SETTING: University hospital. PATIENT(S): Eighty-seven women who underwent COH cycles, either in the GnRH-a long-protocol group (n = 43) or the GnRH antagonist multiple-dose flexible-protocol group (n = 44). INTERVENTION(S): Follicular fluid was obtained from dominant follicles during oocyte retrieval, and FF AMH, inhibin B, E(2), and P concentrations were measured. Serum levels of AMH and inhibin B also were assessed on the day of oocyte retrieval. MAIN OUTCOME MEASURE(S): Follicular fluid AMH and inhibin B concentrations. RESULT(S): Concentrations of serum AMH and inhibin B and of FF AMH, inhibin B, E(2), and P were similar in the two groups. Follicular fluid AMH levels were found to be significantly correlated with age, gonadotropin dose, number of follicles on hCG day, and number of oocytes retrieved. CONCLUSION(S): Our results suggest that there is no significant difference in follicular microenvironment in terms of AMH and inhibin B secretion between GnRH-a and GnRH antagonist protocols and that FF AMH is a marker that reflects ovarian reserve and response to COH.
ISSN
1556-5653 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18249372

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6K-4RRXJBM-2-1&_cdi=5033&_user=168665&_orig=search&_coverDate=04%2F30%2F2008&_sk=999109995&view=c&wchp=dGLbVzb-zSkWb&md5=ccacd75050fed578e39cfe6c02df7268&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68082
DOI
https://doi.org/10.1016/j.fertnstert.2007.04.010
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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