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A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men

Cited 8 time in Web of Science Cited 7 time in Scopus
Authors
Jeong, Hyeon; Jeong, Byong Chang; Kwak, Cheol; Lee, Eunsik; Lee, Sang Eun; Kim, Tae Beom
Issue Date
2008-04-29
Publisher
Springer Verlag
Citation
World J Urol. 26(4):395-400
Keywords
AgedAsian Continental Ancestry Group/statistics & numerical dataBiopsy/*methods/*standardsHumansKorea/epidemiologyMaleMiddle AgedProstate-Specific Antigen/*bloodProstatic Neoplasms/blood/ethnology/*pathologyReproducibility of ResultsRetrospective StudiesRisk Factors
Abstract
OBJECTIVES: To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS: We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 core biopsy and 468 sextant biopsy of the prostate. The cancer detection rates achieved by these two methods were analyzed at different PSAD levels. RESULTS: All patients were stratified into 5 groups according to PSAD level; group A: PSAD < 0.1 (n = 290), group B: 0.1 < or = PSAD < 0.2 (n = 572), group C: 0.2 < or = PSAD < 0.3 (n = 248), group D: 0.3 < or = PSAD < 0.4 (n = 122), and group E: PSAD > or = 0.4 (n = 231). In group B, 12 core biopsy had a higher detection rate than 6 core biopsy (P = 0.017). CONCLUSIONS: These results demonstrate 12 core biopsy is better able to detect cancer than 6 core biopsy in patients with a PSAD in the range 0.1-0.2, which suggests that PSAD be considered when deciding on the number of prostate biopsy cores required.
ISSN
0724-4983 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18438670

http://www.springerlink.com/content/62905x30r439ju6x/fulltext.pdf

https://hdl.handle.net/10371/68083
DOI
https://doi.org/10.1007/s00345-008-0264-1
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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