S-Space College of Medicine/School of Medicine (의과대학/대학원) Urology (비뇨기과학전공) Journal Papers (저널논문_비뇨기과학전공)
A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men
- Jeong, Hyeon; Jeong, Byong Chang; Kwak, Cheol; Lee, Eunsik; Lee, Sang Eun; Kim, Tae Beom
- Issue Date
- Springer Verlag
- World J Urol. 26(4):395-400
- Aged; Asian Continental Ancestry Group/statistics & numerical data; Biopsy/*methods/*standards; Humans; Korea/epidemiology; Male; Middle Aged; Prostate-Specific Antigen/*blood; Prostatic Neoplasms/blood/ethnology/*pathology; Reproducibility of Results; Retrospective Studies; Risk Factors
- OBJECTIVES: To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS: We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 core biopsy and 468 sextant biopsy of the prostate. The cancer detection rates achieved by these two methods were analyzed at different PSAD levels. RESULTS: All patients were stratified into 5 groups according to PSAD level; group A: PSAD < 0.1 (n = 290), group B: 0.1 < or = PSAD < 0.2 (n = 572), group C: 0.2 < or = PSAD < 0.3 (n = 248), group D: 0.3 < or = PSAD < 0.4 (n = 122), and group E: PSAD > or = 0.4 (n = 231). In group B, 12 core biopsy had a higher detection rate than 6 core biopsy (P = 0.017). CONCLUSIONS: These results demonstrate 12 core biopsy is better able to detect cancer than 6 core biopsy in patients with a PSAD in the range 0.1-0.2, which suggests that PSAD be considered when deciding on the number of prostate biopsy cores required.
- 0724-4983 (Print)
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