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Histologic type, staging, and distribution of germ cell tumors in Korean adults

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Park, Dong Soo; Chung, Moon Kee; Chung, Jae Il; Ahn, Han Jong; Lee, Eun Sik; Choi, Han Yong; Yoon, Duck Ki; Cheon, Jun; Hong, Sung Joon; Lee, Young Goo; Yoon, Sang Min; Kim, Wun Jae; Kim, Hyung Jin; Ryu, Soo Bang; Ro, Jae Y
Issue Date
2008-03-28
Publisher
Elsevier
Citation
Urol Oncol. 2008;26(6):590-594
Keywords
AdultHumansKorea/epidemiologyMaleNeoplasm StagingNeoplasms, Germ Cell and Embryonal/epidemiology/*pathology/therapyPrognosisTesticular Neoplasms/epidemiology/*pathology/therapy
Abstract
OBJECTIVES: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia. METHODS: Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis. RESULTS: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT. CONCLUSIONS: Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.
ISSN
1078-1439 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18367106

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TD3-4RKDHX3-6-F&_cdi=5187&_user=168665&_orig=search&_coverDate=12%2F31%2F2008&_sk=999739993&view=c&wchp=dGLbVtz-zSkWz&md5=8ab62425bbcd4932d9d4191e6bceabae&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68102
DOI
https://doi.org/10.1016/j.urolonc.2007.07.012
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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