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GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord
DC Field | Value | Language |
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dc.contributor.author | Choi, In-Sun | - |
dc.contributor.author | Cho, Jin-Hwa | - |
dc.contributor.author | Jeong, Seok-Gwon | - |
dc.contributor.author | Hong, Jung-Soo | - |
dc.contributor.author | Kim, Sang-Jung | - |
dc.contributor.author | Kim, Jun | - |
dc.contributor.author | Lee, Maan-Gee | - |
dc.contributor.author | Choi, Byung-Ju | - |
dc.contributor.author | Jang, Il-Sung | - |
dc.date.accessioned | 2010-07-01T05:18:19Z | - |
dc.date.available | 2010-07-01T05:18:19Z | - |
dc.date.issued | 2008-02-09 | - |
dc.identifier.citation | Pain. 2008 Aug 138(2):330-342 | en |
dc.identifier.issn | 1872-6623 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18258370 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0K-4RS9STC-5-W&_cdi=4865&_user=168665&_orig=search&_coverDate=08%2F31%2F2008&_sk=998619997&view=c&wchp=dGLbVtb-zSkzS&md5=1417ae4308c4809872c1bc4612164296&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68121 | - |
dc.description.abstract | The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the presence of 3 mM kynurenic acid and 10 microM SR95531. In these conditions, baclofen (30 microM), a selective GABA(B) receptor agonist, greatly reduced the amplitude of glycinergic IPSCs and increased the paired-pulse ratio. Such effects were completely blocked by 3 microM CGP55845, a selective GABA(B) receptor antagonist, indicating that the activation of presynaptic GABA(B) receptors decreases glycinergic synaptic transmission. Glycinergic IPSCs were largely dependent on Ca2+ influxes passing through presynaptic N- and P/Q-type Ca2+ channels, and these channels contributed equally to the baclofen-induced inhibition of glycinergic IPSCs. However, the baclofen-induced inhibition of glycinergic IPSCs was not affected by either 100 microM SQ22536, an adenylyl cyclase inhibitor, or 1 mM Ba2+, a G-protein coupled inwardly rectifying K+ channel blocker. During the train stimulation (10 pulses at 20 Hz), which caused a marked synaptic depression of glycinergic IPSCs, baclofen at a 30 microM concentration completely blocked glycinergic synaptic depression, but at a 3 microM concentration it largely preserved glycinergic synaptic depression. Such GABA(B) receptor-mediated dynamic changes in short-term synaptic plasticity of glycinergic transmission onto SG neurons might contribute to the central processing of sensory signals. | en |
dc.description.sponsorship | We thank Prof. Patria Morris (Kyungpook National
University) for correcting the English. This work was supported by the Korea Science and Engineering Foundation (KOSEF) Grant (No. R01-2006-000-10406-0). I.-S. Choi was supported by Brain Korea 21 Project. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Baclofen/pharmacology | en |
dc.subject | Glycine/antagonists & inhibitors/*physiology | en |
dc.subject | Inhibitory Postsynaptic Potentials/drug effects/physiology | en |
dc.subject | Neural Inhibition/drug effects/*physiology | en |
dc.subject | Neurons/drug effects/physiology | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Receptors, GABA-B/agonists/*physiology | en |
dc.subject | Receptors, Presynaptic/agonists/antagonists & inhibitors/*physiology | en |
dc.subject | Spinal Cord/drug effects/physiology | en |
dc.subject | Substantia Gelatinosa/drug effects/*physiology | en |
dc.subject | Synaptic Transmission/drug effects/*physiology | en |
dc.title | GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최인선 | - |
dc.contributor.AlternativeAuthor | 조진화 | - |
dc.contributor.AlternativeAuthor | 정석권 | - |
dc.contributor.AlternativeAuthor | 홍정수 | - |
dc.contributor.AlternativeAuthor | 김상중 | - |
dc.contributor.AlternativeAuthor | 김준 | - |
dc.contributor.AlternativeAuthor | 이만기 | - |
dc.contributor.AlternativeAuthor | 최병주 | - |
dc.contributor.AlternativeAuthor | 장일성 | - |
dc.identifier.doi | 10.1016/j.pain.2008.01.005 | - |
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